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  4. Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers

Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers

Curr. Issues Mol. Biol., 2023 · DOI: 10.3390/cimb45110539 · Published: October 25, 2023

ImmunologyNeurologyBrain Injury

Simple Explanation

Neuroinflammation significantly affects conditions like stroke or spinal cord injury, influencing their development and resolution. It involves processes like oxidative stress and cell death, which can impair motor function by disrupting neuronal connections. New treatments, such as using bionanomaterials and electrostimulation, are being explored to control the inflammatory response and improve patient outcomes.

Study Duration
Not specified
Participants
Not specified
Evidence Level
Review

Key Findings

  • 1
    Neuroinflammation plays a critical role in the pathophysiology of stroke and spinal cord injury, affecting motor function.
  • 2
    Advanced neuroimaging techniques and biomarkers are used for diagnosing and monitoring neuroinflammation.
  • 3
    Emerging therapies like electrostimulation and bionanomaterials show promise in modulating the inflammatory response and promoting recovery.

Research Summary

Neuroinflammation significantly impacts stroke and spinal cord injury, affecting their pathophysiology, progression, and resolution by involving oxidative stress, damage, and cell death. Diagnosis involves neuroimaging and molecular diagnostics to identify and measure signaling molecules, while new therapies like bionanomaterials and electrostimulation aim to modulate the neuroinflammatory response. The goal is to review the implication of neuroinflammation in the evolution of motor function in stroke and trauma patients, focusing on novel methods and potential biomarkers to aid clinicians.

Practical Implications

Improved Diagnosis

Biomarkers enable early detection and monitoring of disease progression.

Targeted Therapies

Bionanomaterials allow precise delivery of therapeutic agents to affected areas.

Enhanced Rehabilitation

Electrostimulation modulates neuronal activity to improve motor function.

Study Limitations

  • 1
    Heterogeneity of neuroinflammation processes
  • 2
    Variability in patient response to treatments
  • 3
    Challenges in delivering bionanomaterials across the blood-brain barrier

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