Efficacy and mechanism of Wuzi Yanzong pill on the prevention and treatment of EAE

This study investigates the potential of Wuzi Yanzong Pill (WYP), a traditional Chinese medicine, to treat multiple sclerosis (MS) using an animal model called experimental autoimmune encephalomyelitis (EAE). The goal is to understand how WYP affects MS and to provide a basis for its clinical use. The research involved administering WYP to mice with EAE and then observing the impact on their clinical scores, inflammatory markers, and immune responses. The study looked at various factors, including the expression of certain proteins and cytokines in the spleen, brain, and spinal cord. The findings suggest that WYP treatment can alleviate clinical symptoms in EAE mice by regulating inflammatory pathways and inhibiting the expression of inflammatory cytokines. This indicates a potential therapeutic effect of WYP on MS.

• 1
  WYP treatment significantly improved the clinical scores of EAE mice in a dose-dependent manner, indicating an improvement in neurological symptoms.
• 2
  WYP treatment reduced inflammation and demyelination in the spinal cord of EAE mice, suggesting a protective effect on the central nervous system.
• 3
  WYP treatment increased the expression of M2 macrophages and the anti-inflammatory cytokine IL-10, suggesting a shift towards an anti-inflammatory immune response.