Immunology Research

KEY FINDING: Sting expression is increased in activated microglia after SCI, and knockout of Sting in microglia improves neurological function recovery after SCI.

KEY FINDING: The case presents the first reported instance of an abrupt onset of neurological injury secondary to intramedullary spinal cord bleed in Behcet’s syndrome.

KEY FINDING: The JAK/STAT pathway is involved in the proliferation and differentiation of neural stem cells, promoting the regeneration of astrocytes and inducing the differentiation of neurons and oligodendrocytes.

KEY FINDING: Mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) improve disease activity and severity in SSc patients.

KEY FINDING: Organic nanomaterials, like PLGA nanoparticles, can effectively reduce the production of inflammatory factors by astrocytes and restrict glial scarring, improving behavioral performance in rats.

KEY FINDING: There's no significant difference in surgery duration between titanium mesh and bone grafting.

KEY FINDING: Following SCI, increased extracellular ATP serves as a damage-associated molecular pattern signal molecule as it is released from ruptured and apoptotic cells.

KEY FINDING: Both hyperbaric and normobaric oxygen therapy significantly reduced the inflammatory response in the injured spinal cord, as evidenced by transcriptomic analysis and immunohistochemical markers for astrocytes and microglia.

KEY FINDING: Neurosarcoidosis is primarily a relapsing disease, with no patients exhibiting a progressive course in this cohort.

KEY FINDING: HA scaffolds improve MSC survival and inhibit neuroinflammation after SCI, as evidenced by decreased pro-inflammatory cytokines and increased anti-inflammatory cytokines.