Genetics Research

KEY FINDING: Bioinformatics analysis of differentially expressed RNAs after spinal cord injury provides a foundation for in vitro and in vivo experiments on gene molecular targets. Further development is needed to verify their function and explore their mechanisms in organisms.

KEY FINDING: miR-124 acts as one of the key miRNAs regulating neuroinflammation in various CNS pathologies, which may shed light on novel therapies targeting miR-124 for treating CNS insults.

KEY FINDING: BYHWD improved motor function in SCI rats. Specifically, low, medium, and high doses of BYHWD showed improvements, with the high dose showing the most significant effect.

KEY FINDING: Adult canine dermal fibroblasts (ACDFs) treated with eight small molecules (SMs) developed neuron-like morphology, including a round-shaped cell body with branching processes.

KEY FINDING: Chordoma tumors exhibit significant intratumoral heterogeneity, with distinct subpopulations of chordoma cells, fibroblasts, and immune cells.

KEY FINDING: miR-101a-3p expression is significantly decreased in the spinal cord after ischemia/reperfusion injury, while MYCN expression is increased.

KEY FINDING: Identified 445 differentially expressed lncRNAs and 6522 differentially expressed mRNAs in rats after spinal cord hemisection injury.

KEY FINDING: Differentially expressed genes (DEGs) were identified between the rostral and caudal regions at different time points following SCI, including Col3a1, Col1a1, Dcn, Fn1, Kcnk3, and Nrg1.

KEY FINDING: LncRNA MEG3 expression is decreased in ASCI mouse spinal cord tissues and LPS-treated primary microglia and BV2 cells.

KEY FINDING: BG treatment leads to a significant decrease of cell viability in tumor cells but not in bone marrow cells.