Research Progress of Long Non-coding RNAs in Spinal Cord Injury

Spinal cord injury (SCI) leads to loss of motor and sensory functions, impacting life quality and creating a social burden. Long non-coding RNAs (LncRNAs) regulate neurological illnesses. Differentially expressed LncRNAs after SCI influence inflammatory damage, apoptosis, and nerve healing by acting as competitive endogenous RNA (ceRNA). LncRNAs, which are 200-1000 bp non-coding RNAs, have a key regulatory role in various neurological illnesses, including SCI. They can function as ceRNAs, affecting inflammatory damage, apoptosis, and nerve healing. They also significantly regulate neuropathic pain. LncRNAs could serve as molecular regulatory targets for diagnosing, treating, and predicting the outcome of spinal cord injuries. This review summarizes the regulatory role and molecular mechanism of LncRNAs in the development of spinal cord injury.

• 1
  Bioinformatics analysis of differentially expressed RNAs after spinal cord injury provides a foundation for in vitro and in vivo experiments on gene molecular targets. Further development is needed to verify their function and explore their mechanisms in organisms.
• 2
  LncRNAs participate in pathological processes such as apoptosis, inflammatory response, nerve repair, and scar formation at different stages of spinal cord injury, by affecting the activation and inactivation of downstream signaling pathways.
• 3
  LncRNAs also have important regulatory effects on other pathophysiological reactions and complications, such as systemic immunosuppression and autophagy during spinal cord injury.