lncRNA MEG3 restrained the M1 polarization of microglia in acute spinal cord injury through the HuR/A20/NF-κB axis

This study explores the role of lncRNA MEG3 in acute spinal cord injury (ASCI), focusing on its impact on microglia polarization and neuroinflammation. The research investigates how MEG3 affects the M1 polarization of microglia, which contributes to neuroinflammation in ASCI. The study found that lncRNA MEG3 expression is reduced in ASCI and that overexpressing MEG3 can restrain the M1 polarization of microglia, reducing neuroinflammation. This suggests that MEG3 has a protective role in ASCI by modulating the inflammatory response. Further investigation revealed that lncRNA MEG3 regulates microglia polarization through the HuR/A20/NF-κB axis, promoting motor function recovery and reducing neuroinflammation in mice with SCI. This identifies a specific molecular pathway through which MEG3 exerts its beneficial effects.

• 1
  LncRNA MEG3 expression is decreased in ASCI mouse spinal cord tissues and LPS-treated primary microglia and BV2 cells.
• 2
  Overexpression of lncRNA MEG3 restrained the M1 polarization of microglia and neuroinflammation by regulating the NF-κB signaling pathway.
• 3
  LncRNA MEG3 regulates the M1 polarization of microglia through the HuR/A20/NF-κB axis, boosting motor function recovery and neuroinflammation relief in mice with SCI.