Genetics Research

KEY FINDING: A multidisciplinary approach is crucial for managing children with achondroplasia, especially those with foramen magnum stenosis and cervical spine injuries.

KEY FINDING: Certolizumab downregulated the expression of TNF-α, NF-κB, and IL-6, key inflammatory mediators.

KEY FINDING: Oxidative stress, resulting from an imbalance between ROS production and antioxidant defenses, significantly contributes to neurodegenerative diseases.

KEY FINDING: SCI significantly increased FL2 expression in the lesion site and rostral to the lesion at 1 day post-injury.

KEY FINDING: ACY-1215 ameliorated SNI-induced pain starting from Day 7 post-SNI operation, achieving relatively stable efficacy by Day 13 in both male and female mice.

KEY FINDING: STS significantly reduced the levels of inflammatory indices in the LPS-induced rats NSCs inflammation model and improved the viability of rats NSCs following inflammatory injury.

KEY FINDING: DFO increases Schwann cell survival in serum-containing medium following hydrogen peroxide challenge.

KEY FINDING: Spinal cord transection (SCT) surgery led to increased bioluminescence in the brain, particularly in the frontal association cortex (FrA).

KEY FINDING: Teriparatide treatment significantly enhanced motor function recovery post-SCI in rats, as assessed by open field tests and BBB scoring.

KEY FINDING: The fingerprint enhancement (FP-E) algorithm effectively detects and characterizes undergrowth collagen fibers in spinal cord injury samples.