Neural Regen Res, 2022 · DOI: https://doi.org/10.4103/1673-5374.337052 · Published: February 28, 2022
This study investigates the role of long noncoding RNAs (lncRNAs) after spinal cord injury (SCI). The experiment involved inducing a hemisection injury in rats at the T10 spinal level, then analyzing the expression of lncRNAs in the adjacent tissue at different times post-injury. The study identified numerous differentially expressed lncRNAs and mRNAs. These were categorized into expression trends and analyzed for co-expression networks. The results indicated that certain lncRNAs are associated with specific biological processes, such as cell division, inflammation, and synaptic transmission. The researchers suggest that these findings could provide new insights for developing clinical treatments for spinal cord injury by targeting specific lncRNAs and their related pathways.
The findings could lead to the development of targeted therapies that modulate the expression of specific lncRNAs to promote nerve regeneration and functional recovery after SCI.
Understanding the role of lncRNAs in the inflammatory response after SCI could help in developing strategies to control inflammation and promote a more favorable environment for nerve regeneration.
Identifying lncRNAs that regulate synaptic transmission could lead to interventions that enhance synaptic plasticity and improve functional outcomes after SCI.