Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 241-250 of 1,773 results
Cellular and Molecular Neurobiology, 2023 • May 23, 2022
This systematic review provides an overview of the literature on the temporal and cellular expression of TNF after SCI and clarifies the potential for its therapeutic manipulation in SCI. Overall, TNF...
KEY FINDING: TNF expression increases rapidly after SCI in resident cells (neurons, astrocytes, oligodendrocytes, and microglia) and macrophages, underscoring its involvement in the inflammatory response.
Neurotherapeutics, 2022 • May 2, 2022
This study investigates the efficacy of dual HDAC/BRD4 inhibitors, SUM52 and SUM35, in treating neuropathic pain using a spared nerve injury (SNI) model in mice. The results indicate that both SUM52 a...
KEY FINDING: SUM52 and SUM35, administered intranasally, reduced thermal and mechanical hypersensitivity in mice with spared nerve injury (SNI), a model of neuropathic pain.
Neural Regeneration Research, 2022 • April 1, 2022
This review describes the changes in lncRNA and circRNA expression that occur after SCI and how these changes may be related to SCI progression. Current evidence for the roles of lncRNAs and circRNAs ...
KEY FINDING: Numerous lncRNAs and circRNAs are found in the spinal cord after SCI, suggesting that their expression levels change in response to SCI.
The Journal of Spinal Cord Medicine, 2023 • January 1, 2023
This study aimed to explore the potential mechanism of spinal cord injury (SCI) using a rabbit spinal cord hemisection (SCH) model and various experimental techniques. The results demonstrated that in...
KEY FINDING: Inhibiting SP/NK1R signaling can improve spinal cord hemisection (SCH) by inhibiting the release of pro-inflammatory cytokines IL-1β, IKKγ, IL-6 and NF-κB.
Molecular Therapy: Oncolytics, 2022 • September 1, 2022
This study investigated the effect of Cln, a b2-adrenergic receptor agonist, on the bystander effect of HSV-TK/GCV gene therapy in human GBM cells using OECs as vectors. The researchers found that Cln...
KEY FINDING: Cln upregulated Cx43 expression in human GBM cells and OECs.
Neurochemical Research, 2022 • July 16, 2022
This study investigates the role of TIPE2 in mitigating inflammation and neuropathic pain induced by sciatic nerve injury (SNI) in rats, focusing on the underlying mechanism involving TAK1. The experi...
KEY FINDING: TIPE2 exhibits a parabola-like change in expression in the spinal cord and DRG of SNI model rats over time.
Neural Regen Res, 2023 • February 1, 2023
Spinal cord injury (SCI) is now considered not only as an event restricted to the spinal cord but also as a brain neurodegenerative disease because the hippocampus undergoes chronic alterations as a c...
KEY FINDING: Spinal cord injury (SCI) induces cognitive and mood deficits that are not induced by lifestyle changes, drugs of abuse, and combined medication but are related to changes in brain structures involved in cognition and emotion, such as the hippocampus.
Neural Regen Res, 2023 • February 1, 2023
Accumulating evidence has proven that acute SCI and TBI can cause a secondary injury by several bioprocesses. cPLA2, the heavyweight component of cellular signal transduction in inflammatory responses...
KEY FINDING: cPLA2 is vital for the production of diverse inflammatory mediators: a variety of inflammatory mediators are directly or indirectly involved in the pathogenesis of CNS trauma
Neural Regeneration Research, 2023 • February 1, 2023
This systematic review and meta-analysis evaluated the efficacy of gene therapies in preclinical models of spinal cord injury (SCI). The analysis included 71 studies and assessed outcomes like locomot...
KEY FINDING: Gene therapies show an overall improvement in locomotor scores in preclinical models of spinal cord injury.
Neural Regeneration Research, 2023 • February 1, 2023
This study investigated the role of ferroptosis in CFA-induced inflammatory pain in rats. The researchers found evidence of ferroptosis in the spinal cord and DRG tissues of these rats. Intrathecal a...
KEY FINDING: CFA-induced inflammatory pain in rats leads to ferroptosis in the spinal cord and dorsal root ganglion tissues.