Genetics Research

KEY FINDING: Identified 75 differentially expressed aging-circadian rhythm related genes between normal and KOA groups, primarily enriched in the circadian rhythm pathway.

KEY FINDING: IL-18 expression significantly increased in the spinal cord after SCI, suggesting its involvement in the injury response.

KEY FINDING: Bulk RNA sequencing identified 526 upregulated genes and 300 downregulated genes in senescent spinal cords compared to young spinal cords, with pathways related to phagosome function, neuroinflammation, ferroptosis, and necroptosis being enriched.

KEY FINDING: MSC-Exos have low immunogenicity, are more accessible, have improved preservation qualities, and potentially have low carcinogenic risks compared to MSCs.

KEY FINDING: Mice lacking brevican, neurocan, tenascin-C, and tenascin-R (4x KO) exhibited impaired fear memory consolidation, indicated by their inability to retrieve previously learned fear memories.

KEY FINDING: After SCI, oxidative stress markers, such as MDA, TOS, and OSI, and apoptosis markers Cytc and Casp3 showed an increase in levels compared to Group C.

KEY FINDING: SNI led to the downregulation of Vof16 expression in spinal dorsal horn (SDH) of lumbar enlargement.

KEY FINDING: A total of 522 DEGs were filtered. Enrichment analysis of their biological functions and pathways yielded the most closely related results for inflammatory response, regulation of cytokine production, neutrophil chemotaxis and degranulation, angiogenesis, cell death, TNF signaling pathway, and osteoclast differentiation.

KEY FINDING: MiR-21 is upregulated in SCI and has protective effects on neurons through various mechanisms.

KEY FINDING: GA-DM induces apoptosis in human B-cell lymphoma cell lines DB and Toledo, and orchestrates autophagy and apoptosis in the murine B-cell lymphoma cell line A20.