Genetics Research

KEY FINDING: Exo-miR-124 facilitates M2 polarization of microglia through the inhibition of the TLR4 pathway, thereby affecting hippocampal neurogenesis and the recovery of neurological behavior and cognition after TBI.

KEY FINDING: TET3 enhances HUCMSC differentiation into OPCs, evidenced by specific marker expression.

KEY FINDING: PTSD-PRS was significantly associated with higher adjusted odds of PTSD in both cohorts, with a pooled odds ratio (OR) of 1.55 [95% confidence interval (CI) 1.30–1.84, p < 0.001].

KEY FINDING: Nrf2 and NFATC2 levels were reduced in PC12 cells after OGD/R treatment.

KEY FINDING: Oral treatment with 4-methylumbelliferone (4-MU) downregulated PNNs, HA, chondroitin sulfate proteoglycans, and glial fibrillary acidic protein.

KEY FINDING: SIX1 expression increases in microglia following SCI in mice and is positively correlated with the M1 microglia marker iNOS and negatively correlated with the M2 microglia marker Arg1.

KEY FINDING: The patient presented with a rare manifestation of TTR-FAP, specifically spinal cord damage, which is not commonly associated with the c.148G>A (p.Val50Met) mutation.

KEY FINDING: Apelin-13 is significantly downregulated in the injured sites of the SCI model rats since day 14 after modeling.

KEY FINDING: Two hub genes, Cd48 and Mpeg1, were identified and exhibited a strong positive correlation (R = 0.92) and shared similar pathways, suggesting their importance in SCI.

KEY FINDING: SNI induces chronic pain and depressive-like behaviors in mice, evidenced by decreased mechanical pain threshold, thermal pain latency, and reduced exploratory behavior.