Browse the latest research summaries in the field of endocrinology for spinal cord injury patients and caregivers.
Showing 21-30 of 217 results
Frontiers in Endocrinology, 2024 • February 22, 2024
This study investigates the mechanisms behind testosterone deficiency in male rats with spinal cord injury (SCI), focusing on the role of nitric oxide (NO) and lipophagy in Leydig cells. The research ...
KEY FINDING: SCI in rats leads to increased nitric oxide (NO) levels in the testes and decreased lipophagy in Leydig cells, contributing to testosterone deficiency.
Brain, Behavior, & Immunity - Health, 2024 • March 30, 2024
This study examines the role of myelin basic protein (MBP) fragments in inducing neuropathic pain, with a specific focus on the sex-specific effects of MBP84-104. The research demonstrates that MBP84-...
KEY FINDING: MBP84-104 interacts with and inactivates LXRα, a nuclear transcription factor that regulates cholesterol metabolism and inflammation.
Experimental Physiology, 2024 • May 2, 2024
This study investigates the role of ferroptosis in diabetic nephropathy (DN) and the efficacy of the ferroptosis inhibitor SRS 16-86 in DN recovery. The findings show that SRS 16-86 promotes renal fun...
KEY FINDING: SRS 16-86 could improve the recovery of renal function after DN by upregulating glutathione peroxidase 4, glutathione and system xc−light chain and by downregulating the lipid peroxidation markers and 4-hydroxynonenal.
Frontiers in Endocrinology, 2021 • June 10, 2021
This study investigates the protein biomarkers associated with the effectiveness of electroacupuncture (EA) in treating diabetic painful neuropathy (DPN) in rats. The study reveals that EA treatment i...
KEY FINDING: Electroacupuncture (EA) significantly increased the mechanical pain threshold in rats with diabetic painful neuropathy (DPN).
Obes Sci Pract, 2024 • July 23, 2024
This study explores health care providers' (HCPs) views about barriers to AOM use in persons living with SCI/D. HCPs described four main thematic barriers to AOM use in persons with SCI/D: (1) AOM sid...
KEY FINDING: HCPs identified AOM side effects (bowel problems, gastrointestinal distress, skin breakdown, muscle loss) as significant barriers due to potential exacerbation in SCI/D patients.
J Neurosci Res, 2020 • May 1, 2020
The study assessed the effects of treadmill training (TM) and testosterone-enanthate (TE) on musculoskeletal recovery in rats after severe spinal cord injury (SCI). Short-term TM alone did not improve...
KEY FINDING: Treadmill training alone did not improve bone, muscle, or locomotor recovery after severe SCI in rats.
The Journal of Spinal Cord Medicine, 2024 • January 1, 2024
This study used qualitative interviews to explore the consequences of excess weight from the perspective of individuals with SCI. Five key themes emerged: physical health conditions, physical symptoms...
KEY FINDING: Excess weight leads to physical health conditions such as chronic diseases and SCI secondary complications.
Mediators of Inflammation, 2023 • April 10, 2023
This study investigated the effects of AdipoRon on neuropathic pain (NeuP) in mice, focusing on its impact on microglia and the AdipoR1/AMPK pathway. The results showed that AdipoRon alleviated mechan...
KEY FINDING: AdipoRon alleviated mechanical nociception in spared nerve injury (SNI) mice, indicating a reduction in pain sensitivity.
British Journal of Nutrition, 2023 • April 24, 2023
This comprehensive review focuses on the significance of accurately determining energy needs after SCI, highlighting the importance of measuring BMR for nutritional guidance and managing malnutrition ...
KEY FINDING: RMR is 9% greater than BMR in persons with SCI.
The Journal of Spinal Cord Medicine, 2024 • May 8, 2023
This study evaluated the effect of semaglutide on body weight and glycemic control in obese individuals with SCI, finding favorable changes in body composition and glycemic control after 26 weeks of t...
KEY FINDING: After 26 weeks of semaglutide administration, total body weight, fat tissue mass, total body fat percent, and visceral adipose tissue volume decreased.