AdipoRon Engages Microglia to Antinociception through the AdipoR1/AMPK Pathway in SNI Mice

This study investigates the potential of AdipoRon, an adiponectin analog, to alleviate neuropathic pain (NeuP) in mice by targeting microglia, a type of immune cell in the central nervous system. The researchers explored whether AdipoRon could reduce pain by modulating microglia-associated inflammation through the AdipoR1/AMPK pathway, a signaling mechanism involved in inflammation regulation. The findings suggest that AdipoRon may alleviate NeuP by reducing the production of TNF-α, an inflammatory substance, from microglia via the AdipoR1/AMPK pathway.

• 1
  AdipoRon alleviated mechanical nociception in spared nerve injury (SNI) mice, indicating a reduction in pain sensitivity.
• 2
  AdipoRon downregulated TNF-α expression and reduced the number of microglia in the spinal cord of SNI mice, suggesting an anti-inflammatory effect.
• 3
  AdipoRon regulated the AdipoR1/AMPK pathway in both the spinal cord of SNI mice and in BV2 cells (a microglia cell line), indicating a potential mechanism of action.