Browse the latest research summaries in the field of endocrinology for spinal cord injury patients and caregivers.
Showing 11-20 of 217 results
International Journal of Biological Sciences, 2023 • May 8, 2023
This study confirmed that diabetes significantly aggravates SCI and is not conducive to the repair of BSCB integrity. The study revealed that diabetes will mediate Ca2+ influx by inducing the over-exp...
KEY FINDING: Diabetes significantly worsens mitochondrial dysfunction and induces excessive apoptosis of ECs in spinal cord from SCI rat.
Frontiers in Endocrinology, 2023 • May 9, 2023
This study explores the role of chronic intermittent hypobaric hypoxia (CIHH) in treating osteoporosis following spinal cord injury (SCI) in rats. SCI often leads to osteoporosis, and the study invest...
KEY FINDING: CIHH treatment effectively reversed the SCI-induced reduction of bone mineral density (BMD), bone volume to tissue volume, trabecular thickness and number.
Front. Neurosci., 2023 • June 9, 2023
This study investigated the anti-inflammatory and glial-modulatory effects of gonadotropin-releasing hormone (GnRH) and growth hormone (GH) in a rat model of thoracic spinal cord injury (SCI). The fin...
KEY FINDING: Chronic treatment with GH and/or GnRH significantly reduced the expression of pro-inflammatory markers (IL6, IL1B, and iNOS) in the spinal cord tissue of rats with SCI.
Frontiers in Neurology, 2024 • December 11, 2024
This pilot study provides proof-of-concept for the use of TRT + finasteride in men with SCI. The treatment showed promise in improving body composition and musculoskeletal health. The results suggest ...
KEY FINDING: TRT + finasteride consistently increased testosterone and estradiol, while concomitantly reducing dihydrotestosterone.
Nutrients, 2023 • September 27, 2023
This study investigates the causal relationship between lipid metabolites and heel bone mineral density (H-BMD) using a two-sample Mendelian randomization (MR) analysis. The MR analysis identified eig...
KEY FINDING: The study found that acetylcarnitine, propionylcarnitine, hexadecanedioate, tetradecanedioate, myo-inositol, 1-arachidonoylglycerophosphorine, 1-linoleoylglycerophoethanolamine, and epiandrosterone sulfate had a causal relationship with heel bone mineral density (p < 0.05).
Chinese Neurosurgical Journal, 2023 • October 24, 2023
This review addresses the co-occurrence of hyponatremia and diabetes insipidus following acute spinal cord injury (SCI). It highlights the limitations of current theories, which often treat these cond...
KEY FINDING: Hyponatremia and diabetes insipidus frequently co-occur after high acute SCI but are treated as distinct conditions with separate mechanisms.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2024 • January 1, 2024
The findings of the present study in SCI mice demonstrated the following: i) Melatonin increased the expression of the MT2 receptor and activated the Nrf2/Keap1 signal pathway; ii) Melatonin reduced t...
KEY FINDING: Melatonin increased the expression of the MT2 receptor and activated the Nrf2/Keap1 signal pathway.
Translational Andrology and Urology, 2023 • December 21, 2023
Penile implant surgery is a safe and effective treatment for erectile dysfunction but requires careful consideration in medically complex patients. Preoperative diagnostics and counseling are crucial ...
KEY FINDING: Patients with spinal cord injuries may benefit from penile implants for both ED and urinary symptoms, but require careful consideration of dexterity and sensation.
Spinal Cord Series and Cases, 2024 • January 12, 2024
This case report presents the successful use of laparoscopic sleeve gastrectomy (LSG) in a 34-year-old woman with tetraplegia, obesity, and infertility. The patient, who had a spinal cord injury and f...
KEY FINDING: Laparoscopic sleeve gastrectomy (LSG) can be a successful intervention for weight loss in patients with SCI and obesity.
Redox Biology, 2024 • February 28, 2024
This study investigates the role of MST1 in exacerbating spinal cord injury (SCI) in diabetic mice, finding that diabetes induces excessive MST1 activation, impairing motor function and neuronal apopt...
KEY FINDING: Diabetes upregulates MST1, leading to excessive neuronal apoptosis and weakened motor function in SCI mice, while inhibiting MST1 restores antioxidant properties and promotes neuronal survival.