Browse the latest research summaries in the field of endocrinology for spinal cord injury patients and caregivers.
Showing 211-217 of 217 results
Frontiers in Endocrinology, 2020 • July 3, 2020
Osteoporosis, a chronic skeletal disorder common in older adults, leads to fractures due to decreased bone mass. Current treatments are insufficient, making stem cell therapies a promising regenerativ...
KEY FINDING: Mesenchymal stem cells (MSCs) are pivotal candidates for bone regeneration due to their anti-inflammatory and immune-privileged potential, making them ethically less concerning than other stem cell types.
Frontiers in Endocrinology, 2020 • July 17, 2020
This review highlights the potential of zebrafish as a model for personalized regenerative medicine, particularly in the context of endocrine diseases. Zebrafish possess remarkable regenerative capabi...
KEY FINDING: Zebrafish possess regenerative capabilities in various organs, making them suitable for studying regenerative medicine approaches for endocrine disorders like diabetes mellitus.
Cell Metab, 2020 • November 3, 2020
The study investigates the inhibitory environment of the mature CNS, demonstrating its reversibility through glial metabolic reprogramming. Increased glycolysis in glia, mediated by L-lactate and L-2H...
KEY FINDING: Activation of PI3K and EGFR pathways in glial cells significantly enhances axon regeneration in the CNS of Drosophila.
Frontiers in Neuroscience, 2020 • December 17, 2020
This review examines the potential of endocrine therapy for spinal cord injury (SCI) treatment. It discusses the neuroprotective roles of estrogen, testosterone, erythropoietin (EPO), basic fibroblast...
KEY FINDING: Estrogen exhibits neuroprotective effects by reducing oxidative stress, cell death, and inflammation in neurodegenerative diseases and SCI. It activates neuroprotective signaling pathways and promotes the expression of anti-apoptotic factors.
Scientific Reports, 2021 • January 27, 2021
This study investigates the potential neuroprotective role of calcitonin gene-related peptide (CGRP) in diabetic peripheral neuropathy (DPN) using a rat model. The researchers found that dietary capsa...
KEY FINDING: Dietary capsaicin in diabetic rats preserved nociceptive sensation and CGRP levels in the spinal cord and DRG neurons.
Frontiers in Cellular Neuroscience, 2021 • March 8, 2021
The review summarizes the roles of endogenous estrogens, estrogen-based therapies, and estrogen-like molecules on brain homeostasis, especially regarding neurogenesis, gliogenesis, and neuroprotection...
KEY FINDING: Estrogens, including estradiol, promote survival in neurons subjected to stress conditions and may counteract aging-associated cognitive decline and prevent Alzheimer’s disease.
Frontiers in Cell and Developmental Biology, 2021 • March 25, 2021
This review explores the potential of ghrelin as a therapeutic molecule for nervous system injuries. Ghrelin's ability to cross the blood-brain barrier and influence multiple physiological processes m...
KEY FINDING: Ghrelin can modulate downstream signaling cascades in both the developing and adult nervous systems, influencing neurogenesis and neuronal plasticity.