Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 111-120 of 904 results
Nanomaterials, 2023 • May 19, 2023
Gene therapy, particularly using adeno-associated viruses, has shown significant progress in treating neurological diseases, including spinal cord injury and Parkinson’s disease, by targeting the deli...
KEY FINDING: AuNpRs (gold nanoporous rods) function as ROS scavengers in DLR, lowering internal cellular conversion stress and enhancing the efficiency of DLR-induced dopaminergic (iDA) neurons from brain astrocytes.
Front. Surg., 2023 • May 26, 2023
This study evaluated the efficacy of 3D simulation/printing-assisted surgery for metastatic epidural spinal cord compression of the posterior column. The simulated group showed improvements in operati...
KEY FINDING: 3D simulation/printing-assisted surgery significantly reduced operation time compared to the non-simulated group.
Medical Devices: Evidence and Research, 2023 • June 5, 2023
This study evaluated the hemostatic ability of AviteneTM Flowable Collagen Hemostat, produced by combining a modified version of AviteneTM MCH flour with sterile saline. In a porcine model of liver in...
KEY FINDING: The flowable MCH flour mixed with saline provided more precise application and uniform coverage to injured tissues compared to the dry MCH flour alone.
Journal of Nanobiotechnology, 2023 • January 1, 2023
The study introduces M@8G, a nano-delivery platform designed to target and treat secondary spinal cord injury (SCI). M@8G consists of 8-gingerol (8G) loaded into mesoporous polydopamine (M-PDA). Resul...
KEY FINDING: M@8G can penetrate the blood-spinal cord barrier to enrich the spinal cord injury site.
Frontiers in Neuroscience, 2023 • May 31, 2023
This review discusses the application of hydrogels in treating spinal cord injuries (SCI), focusing on their ability to improve the microenvironment at the injury site and promote axon regeneration. C...
KEY FINDING: Hydrogels provide three-dimensional support for neuronal regeneration and axonal extension, which is conducive to cell growth, proliferation and migration and promotes neural reconstruction.
Langmuir, 2023 • August 1, 2023
The study combines experimental QCM and AFM measurements with in silico molecular dynamics and docking simulations to characterize the interaction between bovine serum albumin (BSA) and plasma polymer...
KEY FINDING: BSA is adsorbed on PPPy/I with a high affinity, indicated by an adsorption constant of K = 24.35 μ−1.
BMC Biomedical Engineering, 2023 • August 1, 2023
This study addresses the problem of pressure ulcers (PUs), which disproportionately affect individuals with impaired mobility, leading to tissue damage from prolonged pressure. Effective prevention st...
KEY FINDING: A tunable continuous pressure magnitude and duration monitoring approach is proposed that can account for the accumulated damaging effect of an applied pressure and pressure relief over a prolonged period.
Materials Today Bio, 2023 • July 29, 2023
This paper summarizes the mechanism by which the immune response after PEEK implantation leads to fibrous capsule formation; it also focuses on modification techniques to improve the anti-inflammatory...
KEY FINDING: Inflammation and immune mechanisms after PEEK implantation lead to fibrous capsule formation, which impairs osseointegration.
Journal of Nanobiotechnology, 2023 • August 4, 2023
This study analyzed 359 articles from Web of Science (WoS) published between 1991 and May 2023 to assess the global research trends in extracellular vesicles (EVs) for spinal cord injury (SCI). The an...
KEY FINDING: The number of publications on EVs in SCI has experienced explosive growth starting in 2015.
Frontiers in Bioengineering and Biotechnology, 2023 • August 8, 2023
This study investigates a novel exosome delivery system for treating spinal cord injury (SCI). It utilizes a temperature-sensitive hydrogel to deliver miR-138-modified umbilical cord mesenchymal stem ...
KEY FINDING: miR-138-5p-modified UCMSC-Exos reduced inflammation in BV-2 cells by modulating the NLRP3-caspase1 signaling pathway.