A swift expanding trend of extracellular vesicles in spinal cord injury research: a bibliometric analysis

Journal of Nanobiotechnology, 2023 · DOI: https://doi.org/10.1186/s12951-023-02051-6 · Published: August 4, 2023

Simple Explanation

This review analyzes the scientific progress of extracellular vesicles (EVs) in spinal cord injury (SCI) research using bibliometric methods. The study identifies key research trends, leading countries and institutions, and shifts in research focus over time. The findings aim to provide a comprehensive understanding of the field's development and guide future research directions.

Study Duration

From January 1, 1991, to May 1, 2023

Participants

Not specified

Evidence Level

Not specified

Key Findings

1
The number of publications on EVs in SCI has experienced explosive growth starting in 2015.
2
China and the United States are the leading countries in this research area.
3
The research focus has shifted from pathophysiological factors to more mechanistic and applied domains like hydrogels and therapy.

Research Summary

This study analyzed 359 articles from Web of Science (WoS) published between 1991 and May 2023 to assess the global research trends in extracellular vesicles (EVs) for spinal cord injury (SCI). The analysis revealed a significant increase in publications after 2015, with China and the USA being the most productive countries. The study also identified key research areas and their evolution over time. The findings suggest a shift in research focus towards innovative materials like EVs-loaded hydrogels for injury mitigation and highlight potential collaborations and funding opportunities for future research.

Practical Implications

Resource Allocation

Institutions are expected to allocate more resources towards EVs-loaded hydrogel therapy.

Collaboration Opportunities

Researchers should strengthen international cooperation and communication, particularly with leading scholars from China and the USA.

Strategic Focus

Emphasis should be placed on key topics such as glial cells, neuroregeneration, angiogenesis, cell communication, and hydrogels.

Study Limitations

1
Only English papers from the WoS database were included.
2
New papers published after the search date were not included.
3
The growth trend of the paper may last longer than the mathematical model predicts.

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