Hydrogel scaffolds in the treatment of spinal cord injury: a review

Spinal cord injury (SCI) is a central nervous system disease often caused by accidents, leading to long-term adverse effects. Treatment focuses on improving the microenvironment at the injury site and reconstructing axons. Hydrogels, with their biocompatibility and adjustability, can fill pathological defects and mimic the natural extracellular matrix for cell colonization and axon extension. Composite hydrogel scaffolds, enhanced with different materials, can further improve performance, making them useful in SCI treatment.

• 1
  Hydrogels provide three-dimensional support for neuronal regeneration and axonal extension, which is conducive to cell growth, proliferation and migration and promotes neural reconstruction.
• 2
  Hydrogels act as carriers to load stem cells to the injury site, reducing cell loss and off-targeting.
• 3
  Hydrogels slowly release bioactive factors or chemical drugs for sustained and stable release, enhancing performance.