Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 101-110 of 904 results
Cell Prolif., 2023 • May 1, 2023
This study developed a Col/Tac hydrogel for localized delivery of immunosuppressive agents to improve the repair effects of transplanted aSC by immune regulation and reduction of Tac side effects. The...
KEY FINDING: The Col/Tac hydrogel exhibited suitable mechanical properties and long-term sustained Tac release behaviour.
Orthopaedic Surgery, 2023 • May 1, 2023
This review provides an overview of implant materials used in anterior cervical spine reconstruction after tumor resection, covering their properties, advantages, disadvantages, and clinical applicati...
KEY FINDING: Autogenous bone is osteogenic, retains complete histocompatibility, provides structural support, and has no risk of disease transmission.
J Vis Exp, 2024 • April 2, 2024
This protocol describes a method for disrupting the blood-spinal cord barrier (BSCB) in rats using low-intensity focused ultrasound (LIFU) and microbubbles (MBs). The technique involves animal prepara...
KEY FINDING: The concurrent application of LIFU sonication and MB administration is an effective technique for localized BSCB disruption, indicated by the presence of EBD extravasation into the spinal parenchyma.
Int. J. Mol. Sci., 2023 • March 8, 2023
The study presents a multi-stage bioprocess for expanding rat skin-derived Schwann cells (Sk-SCs) in computer-controlled bioreactors to generate clinically relevant cell numbers for nerve repair. The ...
KEY FINDING: The study demonstrated a 50-fold expansion of skin-derived Schwann cells in a 500 mL bioreactor within one week.
Neurospine, 2023 • March 1, 2023
This review discusses recent advances in strategies aimed at activating endogenous neurogenesis for spinal cord injury (SCI) repair, focusing on tissue engineering, stem cell technology, and physiothe...
KEY FINDING: Biomaterials can be designed to mimic the spinal cord's properties, promote neurogenesis, and improve the microenvironment for nerve regeneration after SCI.
Cell Reports Medicine, 2023 • April 18, 2023
The study leverages an algorithmic class, Gaussian-process (GP)-based Bayesian optimization (BO), to solve the problem of handling optimization in large parameter spaces in neural stimulation. The res...
KEY FINDING: GP-BO efficiently explores the neurostimulation space, outperforming other search strategies after testing only a fraction of the possible combinations.
Advanced Healthcare Materials, 2023 • May 12, 2023
This study investigates the immunogenicity of GelMA hydrogels for spinal cord injury (SCI) treatment, focusing on their impact on the SCI immune microenvironment. The research identifies 3% GelMA-A as...
KEY FINDING: 3% GelMA-A was identified as the optimal hydrogel formulation due to its mechanical properties and cytocompatibility.
Frontiers in Neurology, 2023 • April 26, 2023
This review explores the potential of combining cellular therapy with stem cells and nanoparticles to treat spinal cord injuries (SCI). It highlights the limitations of single treatments and the promi...
KEY FINDING: The combination of nanoparticles and stem cells in animal models of SCI has a positive impact on neuroprotection and neuroregeneration.
Front. Bioeng. Biotechnol., 2023 • May 4, 2023
This corrigendum addresses an error found in Figure 5C of the original article, concerning the SCI group image. The corrected figure is presented, and the authors emphasize that the scientific conclus...
KEY FINDING: The original article contained an error in Figure 5C, where an incorrect image was used for the SCI group.
Heliyon, 2023 • May 9, 2023
The study explores the efficacy of AgNPs on functional recovery after spinal cord injury (SCI) in a rat model. Local AgNPs delivery significantly improved locomotor function and provided neuroprotecti...
KEY FINDING: AgNPs delivery could significantly recover locomotor function and exert neuroprotection through reducing of pro-inflammatory M1 survival in SCI rat model.