Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 121-130 of 904 results
Medicina, 2023 • August 3, 2023
Tissue engineering (TE) is a rapidly evolving biomedical discipline that can play an important role in treating neurogenic bladder dysfunction and compensating for current conventional options’ shortc...
KEY FINDING: ADSC sheet transplantation significantly improved voiding function recovery in rats after SCI and is therefore a promising cell delivery treatment option for NGB related to SCI.
Sensors, 2023 • August 14, 2023
This study describes and validates a methodology to derive clinically relevant wheelchair mobility metrics (WCMMs) from IMUs placed on the wheelchair frame and wheel in real-life settings. The set of ...
KEY FINDING: IMUs can accurately measure wheelchair distance, speed, number of pushes, and turning characteristics in real-world settings.
Journal of Nanobiotechnology, 2023 • July 12, 2023
This study investigates the use of ZIF-8 nanoparticles to promote neural differentiation of DPSCs for SCI treatment. The zeolitic imidazolate framework 8 (ZIF-8) is usually used as a drug and gene del...
KEY FINDING: ZIF-8 promotes neural differentiation and angiogenesis of DPSCs by activating the JNK1/p38 MAPK signaling pathway through the continuous release of Zn2+.
Bioeng Transl Med, 2023 • May 25, 2023
This research introduces a thermosensitive hydrogel-based GPR124 delivery strategy for early intervention in SCI, demonstrating notable physicochemical effects that inhibit BSCB disruption and promote...
KEY FINDING: GPR124 expression decreases post-SCI, and recombinant GPR124 can partially alleviate BSCB disruption by restoring tight junctions and promoting endothelial cell migration and tube formation.
Heliyon, 2023 • September 7, 2023
Spinal cord injury (SCI) is characterized by damage resulting in dysfunction of the spinal cord. Hydrogels are common biomaterials that play an important role in the treatment of SCI. We first discuss...
KEY FINDING: Hydrogels can be crosslinked using various methods, including physical, and chemical crosslinking. The mode of cross-linking affects the mechanical and chemical properties of the hydrogels, and selecting the most appropriate method is an important part of hydrogel design.
PNAS, 2023 • November 10, 2023
This study investigates the role of iron homeostasis in neurogenesis after spinal cord injury (SCI) and introduces polyphenol-based hydrogels as a therapeutic intervention. The hydrogels, composed of ...
KEY FINDING: Iron overloading in the spinal cord is not only indicative of impaired motor function but also crucially contributes to axonal disruption and failure of neuronal regeneration.
J Control Release, 2023 • December 1, 2023
This study explored nanoparticles containing antioxidant enzymes (antioxidant NPs) to neutralize excess ROS at the lesion site and its impact. Overall data suggest that restoring the redox balance a...
KEY FINDING: a single dose of antioxidant NPs, administered intravenously three hours after injury, effectively restored the redox balance at the lesion site, interrupting the secondary injury progression.
Scientific Reports, 2023 • November 4, 2023
Our SCI animal model resulted in NB phenotypes in the SCI group with evidence of an increased ratio of bladder to whole body weight and constant dribbling voiding pattern in voiding spot assays. Multi...
KEY FINDING: SCI mice had greater bladder-to-body weight ratio (p < 0.0001), greater collagen deposition (p = 0.009), and greater smooth-muscle-myosin-heavy-chain isoform A/B ratio (p < 0.0001).
Journal of Healthcare Engineering, 2023 • November 1, 2023
The article regarding the treatment of upper cervical spinal cord injury has been retracted by Hindawi. The retraction is based on an investigation that found evidence of systematic manipulation of th...
KEY FINDING: The investigation uncovered evidence of systematic manipulation of the publication process.
Regen Eng Transl Med, 2023 • September 1, 2023
The results of this study demonstrated successful injection and subsequent gelation of our iPN hydrogel formulation in vivo. PLGA encapsulation may be a promising avenue for combining iPN with pro-reg...
KEY FINDING: Gelation of iPN hydrogels was successful upon subcutaneous injection.