Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 71-80 of 12,052 results
Journal of Neuroinflammation, 2025 • March 1, 2025
This study investigates the effects of HDAC6 inhibition on neuropathic pain using a spared nerve injury (SNI) mouse model and demonstrates that the selective HDAC6 inhibitor ACY-1215 significantly all...
KEY FINDING: ACY-1215 ameliorated SNI-induced pain starting from Day 7 post-SNI operation, achieving relatively stable efficacy by Day 13 in both male and female mice.
Materials Today Bio, 2025 • February 28, 2025
The study introduces a novel acrylated PEGylated poly(glycerol succinate) (APPGS) hydrogel for treating spinal cord injury (SCI) by targeting mitochondrial function. APPGS hydrogel exhibited enhanced ...
KEY FINDING: The APPGS hydrogel was successfully prepared and characterized, exhibiting suitable mechanical, physical, and chemical properties for biomedical applications.
Spinal Cord Series and Cases, 2025 • February 28, 2025
This case report describes the recovery of appetite in a 30-year-old man with a complete spinal cord injury (SCI) after using a direct weight-bearing exoskeleton for walking. The patient, who had lost...
KEY FINDING: A patient with complete SCI (T8, AIS A) experienced a recovery of appetite during exoskeleton-assisted walking therapy after not having an appetite since the injury.
bioRxiv preprint, 2025 • February 28, 2025
This article introduces the Neuromusculoskeletal Modeling (NMSM) Pipeline, a MATLAB-based software package that provides researchers and clinicians working together with state-of-the-art computational...
KEY FINDING: The software predicted that the subject could increase his walking speed by 60% without increasing his metabolic cost per unit time by modifying existing muscle synergy recruitment.
World Journal of Gastroenterology, 2025 • February 28, 2025
Neurosurgical patients face a high risk of stress ulcers and gastrointestinal bleeding due to factors like brain injury, spinal cord injury, and increased intracranial pressure. The review discusses b...
KEY FINDING: Stress ulcers are a significant risk for neurosurgical patients, particularly those with severe brain injuries and elevated intracranial pressure.
Brain Sci., 2025 • February 27, 2025
This study investigates the potential of conditioning electrical stimulation (CES) to enhance outcomes in nerve transfer surgery for treating chronic tetraplegia, using a mouse model. The results indi...
KEY FINDING: CES of donor nerves one week prior to nerve transfer surgery enhanced anatomical and functional measures of innervation of targeted muscles.
PNAS, 2025 • February 27, 2025
We previously showed that decreasing LLPS of RNA–protein granules containing the core stress granule protein G3BP1 accelerates the regeneration of injured PNS axons. Expression of G3BP1’s conserved B-...
KEY FINDING: G3BP1 B-domain expression was found to promote axon regeneration in the transected spinal cord provided with a permissive peripheral nerve graft (PNG) as well as in crushed optic nerve.
PLOS ONE, 2025 • February 27, 2025
This study investigated the role of anoikis-related genes in neuropathic pain (NP), particularly in lumbar disc herniation (LDH). Machine learning algorithms identified six key genes (HGF, MMP13, ABL1...
KEY FINDING: Six key anoikis-related genes (HGF, MMP13, ABL1, ELANE, FASN, and LINC00324) were identified as having diagnostic value for NP.
Acta Histochem. Cytochem., 2025 • February 27, 2025
The study aimed to determine the therapeutic efficacy of immature CiN cell transplantation in a marmoset SCI model. Immature CiN cells were transplanted into a subacute marmoset model of SCI on Day 9 ...
KEY FINDING: Immature CiN cell transplantation partially improves spontaneous motor activity in marmoset models of SCI.
Cureus, 2025 • February 26, 2025
This study investigated the effects of intensive task-oriented training, combining bimanual movement and postural control elements (HABIT-SCI), on individuals with chronic incomplete cervical spinal c...
KEY FINDING: Both cases demonstrated improvements in upper limb function, as measured by the Capabilities of Upper Extremity Test (CUE-T), after the intensive training period.