Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 61-70 of 12,052 results
Acta Neurochirurgica, 2025 • March 3, 2025
This systematic review and meta-analysis evaluated the neuroprotective effects of metformin in rodent models of SCI. It included 23 studies with 1,567 animals. The study demonstrated that metformin en...
KEY FINDING: Metformin significantly enhances locomotor function after SCI in rodent models. It also improves mechanical allodynia and thermal hyperalgesia, indicating pain alleviation.
Journal of Translational Medicine, 2025 • March 3, 2025
This study investigates the effects of Sodium Tanshinone IIA Sulfonate (STS) on promoting the proliferation and differentiation of endogenous neural stem cells (ENSCs) to repair spinal cord injury (SC...
KEY FINDING: STS significantly reduced the levels of inflammatory indices in the LPS-induced rats NSCs inflammation model and improved the viability of rats NSCs following inflammatory injury.
eNeuro, 2025 • March 1, 2025
The study investigates whether combining RhoA;Pten deletion in corticospinal neurons (CSNs) with chemogenetic neuronal stimulation synergistically enhances CS circuit rewiring and forelimb functional ...
KEY FINDING: The combination of RhoA/Pten deletion in corticospinal neurons (CSNs) with chemogenetic neuronal stimulation promotes greater axonal growth and presynaptic bouton formation in CSNs within the spinal cord compared with RhoA;Pten deletion alone.
Cell Proliferation, 2025 • March 1, 2025
This study investigates the role of KDM2B in promoting neurogenic differentiation of mesenchymal stem cells (MSCs) from dental apical papilla (SCAP) and its impact on nerve injury repair in rats. The ...
KEY FINDING: KDM2B promotes neurogenic differentiation in SCAP cells by enhancing the expression of neurogenic markers and neural sphere formation.
Neural Regen Res, 2025 • March 1, 2025
Spinal cord injury (SCI) results in permanent neurological disability and poses significant physical, financial, and psychological challenges. The complexity of SCI pathophysiology necessitates explor...
KEY FINDING: The combination of melatonin and dexamethasone showed suitable neuroprotective activities by reducing neutrophil infiltration, cytokine levels, tissue damage, inducible nitric oxide synthase expression, and apoptosis in SCI-treated mice, and motor recovery was also ameliorated.
中国修复重建外科杂志, 2025 • March 1, 2025
中枢性肢体痉挛是中枢神经系统损伤后的一种常见并发症，其中手屈曲痉挛常导致患者活动能力丧失，降低肌张力、缓解痉挛是恢复肢体功能的前提。 T1 神经根切断术是近年提出的新术式，研究已证实其用于治疗中枢性手屈曲痉挛可行。 本共识从中枢性手屈曲痉挛的病因、症状表现、功能评估以及T1 神经根切断术适应证、手术原则与流程、康复方案等方面进行总结，提出T1 神经根切断术治疗中枢性手屈曲痉挛的规范化方案，供临床医...
KEY FINDING: T1 神经根切断术是近年提出的一种有效缓解中枢性手屈曲痉挛的新术式.
Annals of Clinical and Translational Neurology, 2025 • March 1, 2025
This case report presents a novel approach combining spatiotemporal spinal cord stimulation (SCS) with a real-time triggered exoskeleton (EXS-SCS) to restore walking capability in a patient with compl...
KEY FINDING: After one month of treatment, the patient showed improved muscle strength in her legs, moving from ASIA A to ASIA C.
Neural Regen Res, 2025 • March 1, 2025
This study investigates the role of SHP2 in secondary inflammation following spinal cord injury (SCI). The researchers found that SHP2 enhances secondary inflammation and neuronal damage subsequent to...
KEY FINDING: SHP2 expression is upregulated in microglia at the site of spinal cord injury and in LPS-induced microglia.
Brain Behav Immun, 2025 • March 1, 2025
This study demonstrates that blocking or deleting the neonatal Fc receptor (FcRn) can alleviate neuropathic pain in mice after sciatic nerve injury. The researchers used efgartigimod, an FcRn blocker,...
KEY FINDING: Efgartigimod, an FcRn blocker, alleviated mechanical allodynia when administered either 7 or 28 days post-CCI.
Scientific Reports, 2025 • March 1, 2025
The study performs a comprehensive bioinformatics analysis of multi-omics data to reconstruct the differentiation trajectory of ODC/OPC in SCI, leading to the development of an ODC/OPC differentiation...
KEY FINDING: A novel SCI classification model based on the expression of prognostic differentially expressed ODC/OPC differentiation-related genes (PDEODGs) was proposed, including Low, Median, and High ODC/OPC Score Classifications.