Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 4,061-4,070 of 12,052 results
Pharmaceutics, 2022 • September 2, 2022
This study investigates the molecular effects of a single subcutaneous high-dose G-CSF application upon different regions of the rodent brain. The study reveals minor suppressive or stimulatory effect...
KEY FINDING: G-CSF generally downregulates neurogenic differentiation markers in most brain regions studied.
Inflammation and Regeneration, 2022 • September 2, 2022
This study investigates the mechanism of pericyte-fibroblast transition after spinal cord injury (SCI) and the role of the PDGF-BB/PDGFRβ signaling pathway in this process. The results show that micro...
KEY FINDING: PDGFRβ+ pericytes detach from blood vessel walls and transition into fibroblasts to form fibrotic scar after SCI, indicating a key role in scar formation.
Smart Med., 2022 • September 1, 2022
This review provides an overview of recent research progress in iPSC induction methods and clinical applications. The review comprehensively introduces approaches involving biological, chemical, and p...
KEY FINDING: iPSCs are now widely used to study various clinical diseases of hair follicle defects, myocardial infarction, neurological disorders, liver diseases, and spinal cord injuries.
Inflammation and Regeneration, 2022 • September 1, 2022
This study explored the therapeutic potential of platelet-rich plasma (PRP) for treating multiple sclerosis (MS) in cats, utilizing an ethidium bromide (EB)-induced demyelination model. The research a...
KEY FINDING: PRP had a significant positive effect on motor function of the hindlimbs, with improvements observed as early as day 20.
J Neurosci Res, 2022 • September 1, 2022
Compression spinal cord injuries are a common cause of morbidity in people who experience a spinal cord injury (SCI). Either as a by-product of a traumatic injury or due to nontraumatic conditions su...
KEY FINDING: The review describes current animal models of compressive SCI and evaluated their broader applications. Models that are reproducible, uncomplicated, and adaptable across species and ages have the most potential for translational research.
Molecular Therapy: Oncolytics, 2022 • September 1, 2022
This study investigated the effect of Cln, a b2-adrenergic receptor agonist, on the bystander effect of HSV-TK/GCV gene therapy in human GBM cells using OECs as vectors. The researchers found that Cln...
KEY FINDING: Cln upregulated Cx43 expression in human GBM cells and OECs.
J Vet Intern Med, 2022 • September 1, 2022
This study compared the effects of fentanyl versus a ketamine-dexmedetomidine combination on recovery after spinal surgery in dogs with thoracolumbar intervertebral disc herniation. The primary outcom...
KEY FINDING: There was no significant difference in the time to recovery of ambulation between dogs treated with fentanyl and those treated with ketamine-dexmedetomidine.
Addict Biol, 2022 • September 1, 2022
The study compared the ability of social (peer) versus nonsocial (light/tone) cues to reinstate cocaine seeking in rats and investigated the role of oxytocin (OT) neurons in the paraventricular nucleu...
KEY FINDING: Rats trained with peer cues showed reduced latency to respond during cocaine sessions compared to those trained with light/tone cues, suggesting anticipatory behavior.
BMC Anesthesiology, 2022 • September 1, 2022
This case report describes a rare instance of spinal cord infarction (SCI) secondary to pulmonary embolism (PE)-induced cardiac arrest (CA). The patient, a 72-year-old woman, developed paraplegia afte...
KEY FINDING: A 72-year-old woman developed paraplegia after resuscitation from pulmonary embolism-induced cardiac arrest.
BMC Medicine, 2022 • September 1, 2022
This meta-analysis of 62 clinical trials evaluated the benefits and risks of stem cell therapy for spinal cord injury (SCI), finding that stem cells can lead to improvements in motor function and urin...
KEY FINDING: Stem cell therapy improved the ASIA impairment scale score by at least one grade in 48.9% of patients with spinal cord injury, indicating a slight improvement in sensory and motor function.