A novel cell‑free intrathecal approach with PRP for the treatment of spinal cord multiple sclerosis in cats

Inflammation and Regeneration, 2022 · DOI: https://doi.org/10.1186/s41232-022-00230-w · Published: September 1, 2022

Regenerative Medicine Neurology Veterinary Medicine

Simple Explanation

This study investigates the potential of platelet-rich plasma (PRP) to treat multiple sclerosis (MS) in cats, an autoimmune disease affecting the central nervous system. The research involved injecting PRP into the spinal cords of cats with induced MS and monitoring their motor function, lesion size via MRI, tissue structure, and gene expression. The findings suggest that PRP treatment can improve motor function, reduce lesion size, improve tissue structure, and upregulate nerve growth factors, indicating a potential therapeutic effect for MS.

Study Duration

42 days

Participants

15 adult Persian cats

Evidence Level

Not specified

Key Findings

1
PRP had a significant positive effect on motor function of the hindlimbs, with improvements observed as early as day 20.
2
MRI analysis showed a significant reduction in the size and intensity of lesions in the PRP-treated group compared to the control group.
3
Histopathological and TEM investigations indicated significant improvement in the white matter structure and organization, along with high remyelination capacity, in the PRP-treated group.

Research Summary

This study explored the therapeutic potential of platelet-rich plasma (PRP) for treating multiple sclerosis (MS) in cats, utilizing an ethidium bromide (EB)-induced demyelination model. The research assessed motor function using the BBB scoring system, lesion characteristics through MRI, histopathological changes via light and electron microscopy, and gene expression of key neurotrophic factors. The results indicated that intrathecal injection of PRP led to significant improvements in motor function, lesion size reduction, enhanced remyelination, and upregulation of nerve growth factors, suggesting a promising therapeutic approach for MS.

Practical Implications

Potential MS Treatment

Intrathecal PRP injection may offer a novel therapeutic strategy for managing MS, particularly in cases where conventional treatments are ineffective.

Veterinary Applications

The findings can be directly translated into veterinary practice, providing an alternative or adjunctive therapy for cats suffering from MS or similar demyelinating conditions.

Further Research

This study warrants further investigation into the long-term effects of PRP treatment and its potential synergistic effects with other therapeutic interventions for MS.

Study Limitations

1
Small sample size (15 cats)
2
The study used an induced MS model, which may not fully replicate the complexities of naturally occurring MS in cats
3
Lack of long-term follow-up to assess the durability of PRP's therapeutic effects

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