Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 4,031-4,040 of 12,052 results
Gesundheitswesen, 2023 • September 9, 2022
The study aimed to develop a research agenda for paraplegia resulting from traumatic spinal cord injury using an adapted James Lind Alliance (JLA) approach. Four consecutive online surveys were conduc...
KEY FINDING: 38 unresolved research questions were identified from the initial survey involving 52 participants.
Frontiers in Rehabilitation Sciences, 2022 • September 9, 2022
This multi-center randomized controlled trial compared FES therapy to conventional therapy in individuals with incomplete tetraplegia to improve upper extremity function. The study found that both FES...
KEY FINDING: Both FES therapy and conventional therapy resulted in clinically meaningful improvements in self-care ability for individuals with incomplete tetraplegia.
Neurospine, 2022 • September 9, 2022
This review aims to assess the efficacy of spinal cord stimulation, both epidural (eSCS) and transcutaneous (tSCS), on the return of function in individuals with chronic spinal cord injury. The curren...
KEY FINDING: One hundred eight of 127 patients saw improvement in sensorimotor function, 51 of 70 patients saw improvement in autonomic genitourinary function, 32 of 32 patients saw improvement in autonomic pulmonary function, and 32 of 36 patients saw improvement in autonomic cardiovascular function.
Cells, 2022 • September 8, 2022
This study investigates the neuroprotective effects of melatonin on spinal cord injury (SCI) in mice, focusing on the Nrf2/ARE/NLRP3 pathway. The results demonstrate that melatonin promotes neuromotor...
KEY FINDING: Melatonin promotes the recovery of neuromotor function by inhibiting neuroinflammation and reducing neuronal death.
The Journal of Spinal Cord Medicine, 2024 • September 8, 2022
The mechanisms of the predictive effects of pain severity on school/work functioning in youth with SCI are explained in part by the serial multiple mediator effects of pain interference and social fun...
KEY FINDING: Pain predictive effects on school/work functioning were serially mediated by pain interference and social functioning.
Brain Sci., 2022 • September 8, 2022
This study used wearable sensors to quantify gait parameters in 138 PD patients across different stages of the disease and 56 healthy controls, aiming to identify gait impairments in early and progres...
KEY FINDING: Significant differences in stride length, gait velocity, variability of stride length, heel strike angle, and range of motion of ankle, knee, and hip joints were observed between healthy controls and PD patients in early stages (H–Y I-II).
Journal of NeuroEngineering and Rehabilitation, 2022 • September 8, 2022
This study evaluated the accuracy of a novel algorithm for estimating gait speed in children undergoing rehabilitation using a single ankle-worn inertial sensor. The algorithm showed accurate gait spe...
KEY FINDING: The measurement error of the sensor-based gait speed estimation was low in both standardized (0.01 m/s) and daily life (0.04 m/s) conditions.
Journal of NeuroEngineering and Rehabilitation, 2022 • September 8, 2022
LA features have shown evidence of having construct and concurrent validity, thus demonstrating that LA are a clinically-relevant measure related to lower limb strength, sensation, and spasticity afte...
KEY FINDING: LA features were related to measures of impairment with models explaining 69% and 73% of the variance (R²) in strength and sensation, respectively, and correctly classifying 81.6% (F1-score = 0.814) of the participants into spasticity categories.
Biomedicines, 2022 • September 8, 2022
This study introduces a multimodular conduit composed of PLA fibers within HA modules and pre-cultured Schwann cells to address long-distance axonal regeneration challenges in nerve injuries. The mult...
KEY FINDING: The multimodular conduit promoted directed axon growth from DRG explants, indicating its effectiveness for regenerating long tissue defects in the nervous system.
Frontiers in Neuroscience, 2022 • September 8, 2022
This mini-review discusses the roles of DYRK2 in neuronal morphogenesis, nervous system development, and nervous system diseases. DYRK2 plays a key role in regulating the cytoskeleton, influencing neu...
KEY FINDING: DYRK2 regulates neuronal morphogenesis (e.g., axon growth and branching) by phosphorylating cytoskeletal elements (e.g., doublecortin).