Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 4,021-4,030 of 12,052 results
BMJ Open, 2022 • September 14, 2022
This study protocol outlines a randomized clinical trial to investigate the effects of testosterone treatment (TT) combined with long pulse width stimulation (LPWS) on denervated muscles in individual...
KEY FINDING: The study hypothesizes that TT+LPWS will upregulate protein synthesis pathways, downregulate protein degradation pathways, and increase overall mitochondrial health in denervated muscles.
Journal of Pain Research, 2022 • September 13, 2022
This study investigates the effects of differential target multiplexed spinal cord stimulation (DTMP) and traditional low-rate spinal cord stimulation (LR-SCS) on the mTOR pathway in a neuropathic pai...
KEY FINDING: DTMP and LR-SCS reverse injury-induced changes of the mTOR pathway while treating neuropathic pain.
J Rehabil Med, 2022 • September 13, 2022
This demonstration project showed that ICSO-R 2.0 could be applied to systematically describe (in tabular form) the organization of services of an SCI/D specialized rehabilitation centre in Switzerla...
KEY FINDING: ICSO-R 2.0 categories pertaining to the provider dimension were generally the same across the post-acute and outpatient services.
Sensors, 2022 • September 13, 2022
The paper presents the EXOTIC exoskeleton system, a novel assistive upper limb exoskeleton designed for individuals with complete functional tetraplegia. It aims to provide versatility and control for...
KEY FINDING: The EXOTIC exoskeleton system successfully assisted individuals with complete functional tetraplegia in performing ADLs.
Spinal Cord, 2022 • September 12, 2022
The study assessed the accuracy of self-reported injury level and severity in individuals with chronic SCI compared to clinical examination findings. Participants were more accurate in reporting the r...
KEY FINDING: Ninety-three percent of participants correctly self-reported the anatomical region of their injury.
Journal of Immunology Research, 2022 • September 12, 2022
This paper argues that a miR-34a-3p/PDCD6 axis might be a candidate therapeutic target for treating SCI and that the therapeutic effect of EA is driven through this pathway. The results revealed that m...
KEY FINDING: miR-34a-3p might promote the in vitro differentiation of neural stem cell (NSC) through suppressing PDCD6 and regulating other important neural markers such as fibroblast growth factor receptor 1 (FGFR1), MAP1/2 (MAP kinase kinases 1/2), myelin basic protein (MBP), βIII-tubulin Class III β-tubulin (βIII tubulin), and glial fibrillary acidic protein (GFAP).
Molecular Medicine, 2022 • September 12, 2022
miR-21 has potential against the burden of SCI through suppressing the inflammatory milieu in neural cells, apoptosis inhibition, improving angiogenesis, and synapsis protection. Current understanding...
KEY FINDING: miR-21 overexpression reduces neuroinflammation after SCI by decreasing the expression of inflammatory factors.
Neurochemical Research, 2023 • September 12, 2022
This study investigates the context-dependent effects of the complement peptide C3a on primary mouse astrocytes under different conditions: naive, after chemical ischemia, and after exposure to lipopo...
KEY FINDING: C3a down-regulated the expression of Gfap, C3 and Nes in astrocytes after ischemia, suggesting a reduction in reactive astrocyte markers in this context.
J. Pers. Med., 2022 • September 10, 2022
The discovery of iPSCs has provided a new roadmap for clinical translation research and regeneration therapy. The role of human iPSCs in scientific research was examined and the most common neurodegen...
KEY FINDING: Parkinson’s disease scored highest in iPSC-related research publications, followed by Alzheimer’s disease, based on a PUBMED literature review.
Development, Growth & Differentiation, 2022 • September 9, 2022
The study successfully established neural stem cell cultures from the central nervous system of the Iberian ribbed newt (Pleurodeles waltl), demonstrating the formation of neurospheres from brain- and...
KEY FINDING: Neurospheres can be generated from both brain- and spinal cord-derived cells of post-metamorphic P. waltl using a standard neurosphere culture method.