Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 4,041-4,050 of 12,052 results
BioMed Research International, 2022 • September 7, 2022
This retrospective study investigated predictive factors for late-onset neurological deficits in patients with posttuberculous thoracic kyphosis. The study found that a larger spinal cord sagittal dia...
KEY FINDING: Patients with neurological symptoms had a significantly greater spinal cord sagittal diameter ratio (SDR) and a smaller spinal cord angle (SCA) compared to those without symptoms.
Medicina, 2022 • September 7, 2022
This case report describes a spinal cord injury following cervical interlaminar epidural steroid injection (CIESI) in a 35-year-old woman, highlighting potential risks and complications associated wit...
KEY FINDING: Fluoroscopy does not guarantee the prevention of spinal cord penetration during CIESI procedures.
Frontiers in Neuroscience, 2022 • September 7, 2022
This study systematically reviews the therapeutic and prognostic role of HMGB1-targeted therapy in TSCI, identifying and analyzing 170 studies to narrow down to 12 based on inclusion/exclusion criteri...
KEY FINDING: HMGB1-targeted therapy improves locomotor function, reduces inflammation, attenuates edema, and reduces apoptosis in rats and mice with TSCI.
Neurospine, 2022 • September 7, 2022
Acute traumatic SCI can leave a lasting impact on the overall well-being of an individual. For urgent cases associated with severe neurological dysfunction, it is crucial to provide emergency, rapid, ...
KEY FINDING: Patients admitted directly to level I trauma centers had significantly higher odds of receiving a decompressive surgery compared to those who were either transferred to a level I center or went directly to a level II/III/IV center.
Frontiers in Cellular Neuroscience, 2022 • September 7, 2022
This systematic review examined 1,149 spinal cord injury (SCI) clinical trials from ClinicalTrials.gov to analyze trends in interventions, outcomes, and reporting practices. The analysis revealed an i...
KEY FINDING: The number of new SCI clinical trials initiated each year continues to grow, with 50% of all SCI clinical trials initiated between 2016 and 2021.
Frontiers in Molecular Neuroscience, 2022 • September 7, 2022
This review focuses on the unique advantages of using zebrafish larvae as a model for studying spinal cord regeneration, emphasizing their optical transparency, simple anatomy, and complex locomotor b...
KEY FINDING: Spinal cord regeneration in zebrafish larvae is distinct from development, with injury-dependent responses such as immune cell infiltration and glial bridge formation.
PLOS ONE, 2022 • September 6, 2022
This study aimed to investigate the effects of miR-31 on the migration of bone marrow mesenchymal stem cells (BMSCs) and the regulation of MMP-2 and CXCR4 expression in vitro and in vivo. In vitro exp...
KEY FINDING: MiR-31 promotes the proliferation of BMSCs in vitro, as demonstrated by CCK-8 and Cell-cycle assays.
World Journal of Clinical Cases, 2022 • September 6, 2022
This case report details a 59-year-old woman with cervical spinal cord myelopathy who experienced life-threatening hypotension after being treated with tamsulosin for neurogenic bladder. The patient's...
KEY FINDING: Tamsulosin, used for neurogenic bladder in a patient with SCI, led to life-threatening hypotension after 9 days of treatment.
BMC Musculoskeletal Disorders, 2022 • September 6, 2022
The study evaluated cartilage measurements using T2 mapping and R2* sequences in monkeys with normal and reduced knee ROM to determine which sequence is better at detecting microstructural cartilage c...
KEY FINDING: MRI-R2* sequence is superior to T2 mapping in the detection of microstructural cartilage changes in knees with limited ROM.
EMBO Mol Med, 2022 • September 5, 2022
This study introduces a new MALDI-MSI workflow for in situ imaging of glycogen, providing spatial quantification of glycogen levels and architecture in tissues. The method reveals heterogeneous glycog...
KEY FINDING: Glycogen distribution is heterogeneous among different tissues and within different regions of the same tissue in both mice and humans.