Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 4,001-4,010 of 12,052 results
Materials Today Bio, 2022 • September 16, 2022
This study introduces a novel sEVs-NGL/T hydrogel for treating spinal cord injury (SCI). The hydrogel combines tannic acid's antioxidant properties with the therapeutic potential of mesenchymal stem c...
KEY FINDING: The sEVs-NGL/T hydrogel exhibited excellent antioxidant properties in vitro, effectively scavenging DPPH radicals and reducing H2O2 levels.
Frontiers in Surgery, 2022 • September 16, 2022
This study evaluated the impact of early extensive posterior decompression on neurological outcomes in patients with severe traumatic cervical spinal cord injury (tcSCI). The results indicated that ea...
KEY FINDING: A significant improvement in neurological function was observed in patients undergoing early extensive decompression by laminoplasty.
Spinal Cord, 2023 • September 16, 2022
This study investigated the feasibility of using a published algorithm to identify co-occurring TBI in patients with TSCI. The study found that the algorithm was difficult to apply consistently due to...
KEY FINDING: Co-occurring TBI was identified in 39% of TSCI cases, with an additional proportion of suspected cases, potentially raising the total to 55%.
STAR Protocols, 2022 • September 16, 2022
Alternative lengthening of telomeres (ALT) is a telomerase-independent but recombination-dependent pathway that maintains telomeres. Here, we describe a protocol to stimulate the formation of ALT-asso...
KEY FINDING: ABA-dependent tethering of PML-IV to telomeres induces telomere clustering.
Acta Neuropathologica, 2022 • September 16, 2022
The study generated an integrated cell type-specific transcriptomic atlas of MS pathology spanning three major CNS sites including leukocortical, cerebellar and spinal cord areas. The study identified...
KEY FINDING: While we found strong cross-regional diversity among glial subtypes in control tissue, regional signatures become more obscure in MS.
Frontiers in Molecular Neuroscience, 2022 • September 16, 2022
Spinal cord injury (SCI) presents a significant medical challenge due to the chronic inflammation that impedes recovery and the formation of glial scars by astrocytes, which hinder axonal regeneration...
KEY FINDING: Ethyl pyruvate (EP) inhibits the expression of various inflammatory mediators and eliminates the release of oxidative stress factors, thus exerting potent anti-inflammatory roles.
Frontiers in Bioengineering and Biotechnology, 2022 • September 15, 2022
The study successfully fabricated FA-PEG/ZIF-8 nanoparticles, demonstrating their potential to restore function in vivo by selectively eliminating pro-inflammatory microglia/macrophages (M/Ms) without...
KEY FINDING: FA-PEG/ZIF-8 treatment significantly eliminated pro-inflammatory M/Ms in vivo without targeting other nerve cells and downregulated inflammation in the injured lesion.
Frontiers in Surgery, 2022 • September 15, 2022
This study reviewed 85 patients with failed posterior fossa decompression (PFD) for syringomyelia between 2015 and 2019. The patients were categorized into three groups based on the cause of PFD failu...
KEY FINDING: Recurrent cerebrospinal fluid flow obstruction at the foramen magnum is not the only cause of PFD failure; spinal pathologies and craniocervical instabilities can also contribute.
Cureus, 2022 • September 15, 2022
This article presents two case reports of elderly male patients who developed transverse myelitis (TM) as a complication of SARS-CoV-2 infection. Both patients experienced lower extremity weakness, se...
KEY FINDING: Both patients developed acute TM following SARS-CoV-2 infection, despite only exhibiting mild or no classic COVID-19 symptoms.
Annals of Medicine and Surgery, 2022 • September 15, 2022
This case report discusses a rare presentation of primary spinal non-Hodgkin lymphoma in a 32-year-old male who presented with symptoms of impending cauda equina syndrome. The patient was successfully...
KEY FINDING: Primary spinal epidural diffuse large B-cell lymphoma should be considered in patients presenting with back pain and signs of impending cauda equina syndrome.