Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 3,991-4,000 of 12,052 results
Spinal Cord Series and Cases, 2022 • September 20, 2022
The study analyzed data from 4,562 persons with SCI who were tested for COVID-19 between March and July 2020. The case fatality rate for persons with SCI and a positive test for COVID-19 was 12%, high...
KEY FINDING: African Americans had increased odds of testing positive for COVID-19.
Journal of Rehabilitation and Assistive Technologies Engineering, 2022 • September 20, 2022
This study assessed the feasibility of integrating a hand exoskeleton (HERO) into clinic and home rehabilitation programs for stroke and SCI patients and evaluated its orthotic and restorative potenti...
KEY FINDING: The exoskeleton-supported therapy program with in-clinic and at-home training was feasible for stroke and SCI patients.
PLoS Biology, 2022 • September 20, 2022
The study investigates the potential of CBP/p300 activation to promote neurological recovery in chronic SCI with severe disability using the CBP/p300 activator CSP-TTK21 in mice. CSP-TTK21 enhanced re...
KEY FINDING: CSP-TTK21 enhanced classical regenerative signalling in dorsal root ganglia sensory neurons but not cortical motor neurons.
Frontiers in Neuroscience, 2022 • September 20, 2022
This review challenges the traditional view of astrocytes as inhibitors of axon regeneration in the injured CNS, highlighting evidence that supports their positive role in axon growth. Astrocytes' cap...
KEY FINDING: Astrocytes can support axon regeneration under experimental conditions that enhance axons’ intrinsic capacity to grow, such as through Pten gene deletion.
Scientific Reports, 2022 • September 19, 2022
The study investigated the preventive effects of grape stalk extract (GSE) and coffee extract (CE) on central neuropathic pain (CNP) development in spinal cord-injured mice. GSE and CE treatments modu...
KEY FINDING: GSE and CE treatments modulated pain behaviors, reducing thermal hyperalgesia and mechanical allodynia in SCI mice.
Cellular and Molecular Neurobiology, 2023 • September 19, 2022
This study investigated the effects of trehalose-carnosine (Tre–car) conjugate on spinal cord injury (SCI) in both in vitro and in vivo models, focusing on inflammation, apoptosis, and zinc ion homeos...
KEY FINDING: Tre–car conjugate treatment counteracted the activation of the early inflammatory cascade, oxidative stress and apoptosis after SCI.
Medicina, 2022 • September 19, 2022
The study aimed to differentiate NRROPs from RA based on imaging characteristics, as treatment strategies differ for each condition. The study found that NRROPs are characterized by significant retro-...
KEY FINDING: NRROPs showed more prominent retro-odontoid soft tissue thickening compared to RA.
Irish Journal of Medical Science (1971 -), 2022 • September 19, 2022
The study analyzed data from a national tertiary referral center between 2016 and 2020, focusing on elderly patients (≥ 65 years) with traumatic cervical spine injuries and associated neurological def...
KEY FINDING: Complete SCIs are associated with increased length of stay, postoperative complications, life-threatening complications, and 90-day mortality compared to incomplete SCIs.
Cells, 2022 • September 17, 2022
The neurotransmitter GABA is normally characterized as having an inhibitory effect on neural activity in the adult central nervous system (CNS), which quells over-excitation and limits neural plastici...
KEY FINDING: Spinal cord injury (SCI) can bring about a modification that weakens the inhibitory effect of GABA in the central gray caudal to injury.
Genes, 2022 • September 16, 2022
This study investigates the molecular basis of adipose-derived stem cell (ASC) differentiation into chondrocytes, using canine material, to serve as a transcriptomic reference for further research aim...
KEY FINDING: Several genes (e.g., MMP12, MPEG1, CHI3L1, and CD36) were identified as potential new markers of chondrogenesis. These genes could indicate how culture conditions affect ASCs.