Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 3,951-3,960 of 12,052 results
Top Spinal Cord Inj Rehabil, 2022 • October 1, 2022
This study investigated whether thermoregulatory sweating and active vasodilation in skin are controlled by separate nerves during passive heat stress in persons with spinal cord injury (SCI). The stu...
KEY FINDING: In persons with tetraplegia, there was no sweating in any measured dermatome.
Top Spinal Cord Inj Rehabil, 2022 • October 1, 2022
This study investigates the efficacy of telepsychology, specifically video-based CBT, for individuals with SCI to address depression and improve well-being. Participants within one year of SCI are ran...
KEY FINDING: The study anticipates that participants receiving tele-CBT will experience improvements in depressive and anxiety symptoms and increased life satisfaction compared to those receiving usual care.
Top Spinal Cord Inj Rehabil, 2022 • October 1, 2022
This phase I randomized controlled trial will investigate the effectiveness of cognitive multisensory rehabilitation (CMR) for neuropathic pain relief in adults with spinal cord injury (SCI). The stud...
KEY FINDING: The study aims to determine baseline differences in brain function between adults with SCI and uninjured controls using fMRI.
Dose-Response: An International Journal, 2022 • October 1, 2022
This study used iTRAQ proteomics to investigate the molecular mechanisms of hyperbaric oxygen therapy (HBOT) in a rat model of spinal cord injury (SCI). The study identified differentially expressed p...
KEY FINDING: HBOT influences biological processes such as oxygen transport, gas transport and regulation of T cell proliferation.
International Journal of Nursing Studies Advances, 2022 • October 1, 2022
This 10-year longitudinal qualitative study explored the experiences of individuals living with spinal cord injury to identify factors crucial for a fulfilled life. The study found that adapting to li...
KEY FINDING: A satisfying life can be led despite limitations caused by spinal cord injury by balancing possibilities and the life wished for.
Neural Regeneration Research, 2022 • October 1, 2022
In summary, graphene and graphene-based materials have considerable potential as scaffold materials for nerve tissue engineering that promote axon repair and regeneration. They provide a new means of ...
KEY FINDING: Graphene and graphene-based materials are used in the treatment of SCI because of their good biocompatibility, neuronal induced orientation, adsorption, electrical conductivity, and flexibility.
NEURAL REGENERATION RESEARCH, 2022 • October 1, 2022
This review discusses the critical roles of the mTOR pathway in axon regeneration in different types of CNS injury and demonstrates that the reactivation of this regenerative pathway can be achieved b...
KEY FINDING: mTOR signaling is the intrinsic axon regenerative pathway, and its reactivation can promote axon regeneration after adult CNS injury.
Glia, 2022 • October 1, 2022
This study demonstrates the capacity of digoxin to induce OPC differentiation in vitro, to robustly stimulate myelination in vivo in the chemically-induced cuprizone and lysophosphatidylcholine (LPC) ...
KEY FINDING: Digoxin regulated multiple genes in oligodendrocyte progenitor cells (OPCs) essential for oligodendrocyte (OL) differentiation in vitro, promoted OL differentiation both in vitro and in vivo in female naïve C57BL/6J (B6) mice, and stimulated recovery of myelinated axons in B6 mice following demyelination in the corpus callosum induced by cuprizone and spinal cord demyelination induced by lysophosphatidylcholine (LPC), respectively.
Computational and Mathematical Methods in Medicine, 2022 • October 1, 2022
This study explores the role of TRIM28 in LIHC, finding that its expression is upregulated in tumors and associated with poor prognosis. The research identifies correlations between TRIM28 expression ...
KEY FINDING: High TRIM28 expression level was associated with T classification, pathologic stage, histologic grade, and serum AFP levels.
Neurotherapeutics, 2022 • September 30, 2022
The study developed a high-throughput screening assay (HTSA) to identify drugs protecting the blood-brain spinal cord barrier (BBSCB). Screening 1,570 drugs identified berberine and mubritinib as cand...
KEY FINDING: Berberine and mubritinib protected BBSCB from oxygen–glucose deprivation and reoxygenation stress in vitro.