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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Latest Research Summaries

Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.

Showing 3,961-3,970 of 12,052 results

PharmacologyMental HealthBrain Injury

Correction to: Association of day-of-injury plasma glial fibrillary acidic protein concentration and six-month posttraumatic stress disorder in patients with mild traumatic brain injury

Neuropsychopharmacology, 2022 • September 30, 2022

This article is a correction to a previously published study concerning the association of GFAP concentration and posttraumatic stress disorder in patients with mild traumatic brain injury. The correc...

KEY FINDING: The primary finding is a correction of the material measured; GFAP was measured in plasma, not serum, in the original study.

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Spinal Cord InjuryPain ManagementRehabilitation

The Impact of Activity-Based Interventions on Neuropathic Pain in Experimental Spinal Cord Injury

Cells, 2022 • September 30, 2022

This review examines the potential of activity-based interventions (ABI) to alleviate neuropathic pain (NP) following spinal cord injury (SCI) in preclinical rodent models. It focuses on molecular and...

KEY FINDING: Weight-bearing rhythmic activity-based paradigms seem effective for neuropathic pain relief after spinal cord injury, regardless of whether interventions are started early or delayed, or applied for short or long durations, but the benefits may not persist long after halting the interventions.

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NeurologyPain ManagementSpinal Disorders

Spinal cord stimulator medullary compression—a very rare SCS complication and surgical treatment

Spinal Cord Series and Cases, 2022 • September 30, 2022

This case report describes a rare instance of spinal cord compression caused by a spinal cord stimulator (SCS) electrode array in a 58-year-old woman with a history of back pain and multiple spine sur...

KEY FINDING: The case report highlights a very rare complication of SCS, spinal cord compression due to the electrode array.

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Spinal Cord InjuryPain ManagementGenetics

Lysophosphatidic Acid Induced Apoptosis, DNA Damage, and Oxidative Stress in Spinal Cord Neurons by Upregulating LPA4/ LPA6 Receptors

Mediators of Inflammation, 2022 • September 30, 2022

The study investigates the effects of LPA on spinal cord neurons, particularly concerning cytotoxicity, apoptosis, DNA damage, and oxidative stress, using an in vitro model. It finds that LPA (18:1) n...

KEY FINDING: LPA (18:1) treatment decreases cell viability and increases LDH release in spinal cord neurons, indicating cytotoxicity.

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Spinal Cord InjurySurgeryOrthopedics

The Efficacy of Anterior Cervical Corpectomy and Fusion and Posterior Total Laminectomy on Cervical Spinal Cord Injury and Quality of Life

Computational and Mathematical Methods in Medicine, 2022 • September 29, 2022

This study compared anterior cervical corpectomy and fusion with posterior total laminectomy for treating cervical spinal cord injury. The anterior approach showed benefits in perioperative indicators...

KEY FINDING: The amount of blood loss, wound diameters, operation times, and operation costs were higher in the posterior approach group compared to the anterior approach group.

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Spinal Cord InjuryNeurologyGenetics

Exosomes derived from M2 Macrophages Improve Angiogenesis and Functional Recovery after Spinal Cord Injury through HIF-1α/VEGF Axis

Brain Sci., 2022 • September 29, 2022

This study investigates the pro-angiogenesis of M2 macrophage-derived exosomes on SCI. The findings reveal that M2 macrophage exosomes improve neurological functional recovery and angiogenesis post-SC...

KEY FINDING: M2 macrophage exosomes alleviate tissue damage and enhance functional recovery post-SCI in rats.

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NeurologyBiomedical

Directional Submicrofiber Hydrogel Composite Scaffolds Supporting Neuron Differentiation and Enabling Neurite Alignment

Int. J. Mol. Sci., 2022 • September 29, 2022

This work introduces a cost-efficient gelatin-based submicron patterned hydrogel–fiber composite with tuned stiffness, able to support cell attachment, differentiation and alignment of neurons derived f...

KEY FINDING: Fiber–hydrogel composites with a modulus of about 20 kPa showed the strongest cell attachment and highest cell proliferation, rendering them an ideal differentiation support.

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Assistive TechnologyBioinformaticsRehabilitation

Classification of Wheelchair Related Shoulder Loading Activities from Wearable Sensor Data: A Machine Learning Approach

Sensors, 2022 • September 29, 2022

This study developed and validated a methodology for classifying wheelchair-related shoulder-loading activities (SL-ADL) using wearable sensor data and deep learning. A deep learning model, incorporat...

KEY FINDING: The trained deep learning algorithm achieved an overall accuracy of 98% in classifying wheelchair-related shoulder-loading activities (SL-ADL).

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NeurologyRehabilitation

Reasons and Determinants of BoNT-A Treatment Discontinuation in Patients Living with Spasticity: A 10-Year Retrospective Analysis

Toxins, 2022 • September 29, 2022

This retrospective study analyzed the reasons for discontinuation of Botulinum Toxin A (BoNT-A) treatment in 56 patients with spasticity due to stroke, multiple sclerosis, spinal cord injury, or traum...

KEY FINDING: Logistic reasons (including distance problems and difficulty in being accompanied) were the most common reason reported for treatment discontinuation (21, [37.5%]), especially in stroke patients

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Spinal Cord InjuryImmunologyNeurology

Acute Systemic White Blood Cell Changes following Degenerative Cervical Myelopathy (DCM) in a Mouse Model

Int. J. Mol. Sci., 2022 • September 29, 2022

This study examined the temporal profile of circulating white blood cells during the progression of DCM in a mouse model. The research aimed to identify potential systemic hematological changes that c...

KEY FINDING: Circulating monocytes increased four-fold at 3 weeks following DCM induction, but these differences normalized at subsequent time points.

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