Browse the latest research summaries in the field of research methodology & design for spinal cord injury patients and caregivers.
Showing 641-650 of 702 results
JOR Spine, 2024 • January 1, 2024
This study examines the impact of repetitive violent injuries on intervertebral disc degeneration (IVDD) using an organ culture model. The results indicate that repetitive high-force loading leads to ...
KEY FINDING: Repetitive one strike loading led to early disc degeneration, indicated by decreased dynamic compression stiffness.
Intensive Care Medicine Experimental, 2024 • January 10, 2024
This review summarizes translational research using zebrafish to study sepsis, organ failure, and trauma, highlighting technologies applicable in this model organism. Zebrafish models allow visualizat...
KEY FINDING: LPS-induced zebrafish endotoxemia results in extravascular migration of neutrophils and macrophages and changes in the expression of tight junction proteins.
Frontiers in Cellular Neuroscience, 2024 • January 16, 2024
This study investigated 3,359 documents published from 1994 to 2023 regarding apoptosis and SCI. Among all the relevant countries, China ranked the first in aspect of the overall number of publication...
KEY FINDING: The USA and China were the most productive countries in apoptosis and SCI research.
J. Clin. Med., 2024 • March 8, 2024
This meta-analysis provides the summary estimates for perioperative and postoperative functional outcome and safety of endoscopic treatment options for BPO in patients ≥75 years of age. Of particular ...
KEY FINDING: All surgical techniques significantly improve the postoperative quality of life of patients in this age group compared to their preoperative quality of life.
MedComm, 2024 • February 2, 2024
The study investigates the impact of early durotomy on functional recovery, tissue sparing, inflammation, and tissue stiffness after SCI in rats. Durotomy was performed 24 hours post-injury. Results s...
KEY FINDING: Durotomy significantly promoted the recovery of hindlimb locomotor function, as shown by improved BBB scores compared to laminectomy alone.
ZEBRAFISH, 2024 • April 1, 2024
This study examines the effects of different diets on the growth and spinal cord regeneration of larval zebrafish. Three diets were compared: live rotifers, a commercial powder diet, and nutritive med...
KEY FINDING: Larvae fed a live rotifer diet grew 32% in length, while those fed a commercial diet only grew 4%.
Nature Communications, 2024 • June 14, 2024
This study identifies dos-3 as a key gene mediating the cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of germline stem/progenitor cells (GSPCs) in C. elegans. DOS-3, a non-...
KEY FINDING: dos-3 encodes a non-canonical Notch ligand and is upregulated by DAF-16/FOXO activity in aging PSG cells of animals with reduced IIS.
Journal of Extracellular Biology, 2023 • September 17, 2023
In this perspective paper, we aim to raise awareness of the effects of cell culturing parameters (Figure 2a) that may affect EV release (Figure 2b), biochemical composition, and/or function (Figure 2c...
KEY FINDING: Different cells may have different basal rates of EV production. For example, EV yield and function may differ between MSCs derived from different donors and tissue sources
JOR Spine, 2024 • June 20, 2024
The study successfully developed and validated a mouse model of chronic ventral spinal cord compression, mimicking the pathophysiology of OPLL in humans. The Enpp1flox/flox/EIIa-Cre mice exhibited pro...
KEY FINDING: Enpp1flox/flox/EIIa-Cre mice exhibited a gradual deterioration of compression in the Enpp1flox/flox/EIIa-Cre mice group as they aged, with a rapid progression between 12 and 20 weeks, followed by stabilization.
Cureus, 2024 • June 21, 2024
Organophosphates (OP) are widely used pesticides that can cause delayed neurotoxicity, a rare condition where neurological symptoms manifest weeks after initial exposure. This case report presents a 2...
KEY FINDING: A 28-year-old male developed delayed myelopathy five weeks after acute chlorpyrifos poisoning, presenting with lower limb weakness, abnormal gait, and sensory loss.