Role of durotomy on function outcome, tissue sparing, inflammation, and tissue stiffness after spinal cord injury in rats

This study investigates whether a surgical procedure called durotomy, which involves opening the protective membrane around the spinal cord, can improve recovery after spinal cord injury (SCI) in rats. The researchers examined the effects of durotomy on various factors, including the ability to move, tissue damage, inflammation, and stiffness of the spinal cord tissue. The findings suggest that early durotomy after SCI can help reduce tissue damage, inflammation, and improve the recovery of tissue elasticity, potentially leading to better functional outcomes.

• 1
  Durotomy significantly promoted the recovery of hindlimb locomotor function, as shown by improved BBB scores compared to laminectomy alone.
• 2
  Radiological analysis revealed that durotomy reduced lesion size and tissue edema in the spinal cord after injury.
• 3
  Durotomy led to decreased cavitation, scar formation, and inflammatory responses in the injured spinal cord tissue.