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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Research Methodology & Design Research

Browse the latest research summaries in the field of research methodology & design for spinal cord injury patients and caregivers.

Showing 631-640 of 702 results

Spinal Cord InjuryResearch Methodology & DesignPublic Health

Sex-related Differences in Epidemiology, Treatment, and Economic Burden of Traumatic Spinal Cord Injury in China (2013–2018)

Spine, 2023 • September 1, 2023

This study analyzed data from 13,465 individuals with TSCI in China between 2013 and 2018, finding that while TSCI is more prevalent in males, the male-to-female ratio is decreasing. The study also re...

KEY FINDING: The average ratio of males to females with TSCI is decreasing.

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PhysiologyGeneticsResearch Methodology & Design

Advanced Methodology for Rapid Isolation of Single Myofibers from Flexor Digitorum Brevis Muscle

TISSUE ENGINEERING: Part C, 2023 • May 24, 2023

This study introduces a time- and cost-effective method for isolating single myofibers from the flexor digitorum brevis (FDB) muscle in both young and aged mice. The protocol modifications, including ...

KEY FINDING: The modified protocol significantly improves the yield of viable, intact myofibers compared to previous methods, achieving approximately 2300–3100 myofibers from two FDB muscles of a single mouse.

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Spinal Cord InjuryBiomedicalResearch Methodology & Design

Composite Fibrin/Carbon Microfiber Implants for Bridging Spinal Cord Injury: A Translational Approach in Pigs

Int. J. Mol. Sci., 2023 • July 5, 2023

This study investigated the use of composite fibrin/carbon microfiber implants for bridging spinal cord injury in a porcine model. The results indicate that myelotomy and lesion debridement can be adv...

KEY FINDING: Myelotomy and lesion debridement alone did not cause further neural damage compared to SCI alone, but had little positive effect on neural regrowth.

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Spinal Cord InjurySurgeryResearch Methodology & Design

Duroplasty for injured cervical spinal cord with uncontrolled swelling: protocol of the DISCUS randomized controlled trial

Trials, 2023 • June 13, 2023

The DISCUS trial is a prospective, phase III, multicenter, randomized controlled superiority trial designed to assess whether the addition of duroplasty to bony decompression improves muscle strength ...

KEY FINDING: The primary objective is to test the hypothesis that, in patients with severe cervical TSCI, bony + dural decompression, compared with bony decompression alone, improves American Spinal Injury Association Impairment Scale (AIS) motor score (AMS) at 6 months.

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Spinal Cord InjuryResearch Methodology & Design

Porcine Models of Spinal Cord Injury

Biomedicines, 2023 • August 4, 2023

Large animal models of spinal cord injury may be useful tools in facilitating the development of translational therapies for spinal cord injury (SCI). Porcine models of SCI are of particular interest ...

KEY FINDING: Porcine models of SCI are of particular interest due to significant anatomic and physiologic similarities to humans, potentially enabling more accurate evaluation of treatments.

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Spinal Cord InjuryMedical ImagingResearch Methodology & Design

Assessment of spinal cord injury using ultrasound elastography in a rabbit model in vivo

Scientific Reports, 2023 • September 26, 2023

This study investigates the feasibility of using ultrasound elastography (USE) to assess spinal cord injury (SCI) in a rabbit model in vivo. The researchers compared USE measurements with histological...

KEY FINDING: USE strain ratios were significantly higher in paralyzed rabbits compared to non-paralyzed rabbits, indicating differences in spinal cord mechanical properties.

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GeneticsResearch Methodology & Design

Author Correction: Enhancer hijacking at the ARHGAP36 locus is associated with connective tissue to bone transformation

Nature Communications, 2023 • October 12, 2023

This is an author correction regarding the funding acknowledgements in the original article published in Nature Communications. The correction replaces a paragraph that incorrectly cited the Baylor-Ho...

KEY FINDING: The correction addresses an error in the acknowledgement of funding sources for genome sequencing.

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Spinal Cord InjuryNeurologyResearch Methodology & Design

Bibliometric and visual analysis of spinal cord injury-associated macrophages from 2002 to 2023

Frontiers in Neurology, 2023 • November 21, 2023

This bibliometric study provides a comprehensive overview of macrophage research in SCI over the past 20 years. It identifies research trends, key contributors, and collaboration patterns in the field...

KEY FINDING: The number of studies on macrophages in SCI has increased, particularly in the United States and China. However, there's a lack of international collaboration.

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Spinal Cord InjuryRegenerative MedicineResearch Methodology & Design

Research hotspots and trend analysis of cell transplantation in traumatic spinal cord injury: a bibliometric and visualized analysis

Frontiers in Pharmacology, 2023 • December 11, 2023

This study analyzes research on cell transplantation for TSCI from 2013 to 2023, identifying key countries, institutions, and researchers in the field. The number of publications in the field showed a...

KEY FINDING: Mainland China and the United States are the leading countries in cell transplantation research for TSCI.

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Spinal Cord InjuryTraumaResearch Methodology & Design

Traumatic spinal cord and spinal column injuries: A bibliometric analysis of the 200 most cited articles

Journal of Craniovertebral Junction and Spine, 2023 • November 29, 2023

This bibliometric analysis identifies the 200 most prominent articles on traumatic spinal cord and spinal column injuries, enabling the identification of impactful work and knowledge gaps. The analysi...

KEY FINDING: The United States contributed the most articles (110), with the University of Toronto being the top institution (34 publications).

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