Browse the latest research summaries in the field of research methodology & design for spinal cord injury patients and caregivers.
Showing 651-660 of 702 results
Stem Cell Research & Therapy, 2024 • July 11, 2024
This clinical trial investigated the safety and feasibility of intravenous administration of allogenic Muse cells for treating human cervical traumatic spinal cord injury (SCI). The study involved 10 ...
KEY FINDING: The study found no serious safety issues with using Muse cells in this way.
Frontiers in Neurology, 2024 • August 5, 2024
This study provides a comprehensive overview of research on SCI and surgical decompression over the past five decades using bibliometric analysis. The analysis identifies key trends, leading countries...
KEY FINDING: The USA and China are the leading countries in SCI and surgical decompression research, with the University of Toronto being the most prolific institution.
Stem Cell Research & Therapy, 2024 • January 1, 2024
This study demonstrated that intrathecal administration of allogeneic HUC-MSCs-exosomes is safe in patients with subacute SCI. Moreover, it seems that this therapy might be associated with potential c...
KEY FINDING: The intrathecal injection of allogeneic HUC-MSCs-exosomes was safe and well tolerated. No early or late adverse event (AE) attributable to the study intervention was observed.
Frontiers in Neurology, 2024 • September 13, 2024
The study identified CELF4 as a central gene associated with immune infiltration among DEGs through bioinformatics analysis of microarray datasets. Previous research indicates that CELF4 may play a cr...
KEY FINDING: A total of 5,151 differentially expressed genes (DEGs) were identified between SP-EP and normal samples. These DEGs are involved in cellular processes like cell cycle regulation and cell sensitivity mechanisms, according to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis.
Medicine, 2024 • September 13, 2024
The results provide valuable information regarding the mechanisms of cell death after spinal cord injury. The observed decline in the number of documents for the year 2023 can be attributed to several...
KEY FINDING: Publications in this field have grown rapidly in the past 2 decades and are expected to keep increasing.
European Journal of Pain, 2025 • January 1, 2025
This translational study examined the interaction between descending inhibitory controls and spinal amplification in pain modulation, using parallel human and rat models. The study found that spinal a...
KEY FINDING: In humans, concurrent application of a noxious conditioning stimulus did not affect pain ratings to a single pinprick stimulus, repetitive stimulation or the wind-up ratio.
Biomater Transl, 2024 • November 15, 2024
Stem cell-derived spinal cord organoids (SCOs) have revolutionised the study of spinal cord development and disease mechanisms, offering a three-dimensional model that recapitulates the complexity of ...
KEY FINDING: SCOs effectively model spinal cord morphogenesis, offering insights into the intricate processes of neural tube formation and regional specification.
Journal of Translational Medicine, 2025 • January 1, 2025
This study provides a comprehensive transcriptomic meta-analysis of rat spinal cord injury (SCI) datasets, integrating diverse experimental models based on injury severity and time post-injury. The re...
KEY FINDING: The study identified severity-specific biomarker genes that allow precise classification of transcriptomic profiles, indicating potential for injury prognosis prediction.
Journal of Neurochemistry, 2025 • February 3, 2025
The study introduces a novel tamoxifen-inducible PDGFRβ+ cell ablation model in mice to investigate pericyte responses in the CNS following acute ablation, addressing limitations in existing models. T...
KEY FINDING: A low dose of tamoxifen effectively ablates PDGFRβ+ cells of the CNS in mice without reducing survival or causing significant systemic side effects, such as weight loss.
Brain Res, 2015 • September 4, 2015
This review discusses the California Spinal Cord Consortium's (CSCC) work in developing a translational non-human primate model for spinal cord injury (SCI). The CSCC employs a biomedical informatics ...
KEY FINDING: The study highlights the development of a comprehensive preclinical data record for non-human primate SCI studies, including functional behavior, electrophysiology, kinematics, in vivo MRI, postmortem histopathology, and a full medical record.