Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 901-910 of 2,298 results
Stem Cell Research & Therapy, 2021 • May 14, 2021
This study explored the therapeutic effects of hADSC and hADSC-Exo on wound healing and cutaneous regeneration in a mouse model. The findings demonstrate that combined treatment with hADSC and hADSC-E...
KEY FINDING: Combined application of local hADSC-Exo smearing and hADSC/hADSC-Exo intravenous administration promoted wound healing and accelerated re-epithelialization.
Cell Regeneration, 2021 • March 15, 2021
This study investigates the expression and function of the melanocortin 4 receptor (MC4R) in mouse limb and digit regeneration. It utilizes Mc4r-gfp mice to track MC4R expression during development an...
KEY FINDING: Mc4r expression in the mouse limb and digit is closely related to nerve tissues.
eLife, 2021 • May 6, 2021
The study demonstrates that Hh signaling is necessary for regeneration of muscle and spinal cord in Xenopus larvae. Hh-Smo signaling is particularly important for NSC proliferation with regards to spi...
KEY FINDING: Smoothened (Smo) activity is essential for spinal cord and skeletal muscle regeneration in Xenopus laevis larvae.
Advanced Science, 2021 • February 25, 2021
This study investigates the potential of MgFe-LDH nanoparticles as a replacement for LIF in mESC culture, aiming to provide a chemically defined and xeno-free culture condition. The results demonstrat...
KEY FINDING: MgFe-LDH nanoparticles are superior to MgAl-LDH nanoparticles in maintaining mESC self-renewal and pluripotency under LIF and MEF-free conditions.
Frontiers in Pharmacology, 2021 • April 14, 2021
The study investigates the therapeutic potential of SPF-FB, a protein and lipid fraction derived from Arabian Gulf catfish epidermal gel secretion, in treating sciatic nerve crush injury in rats. SPF-F...
KEY FINDING: SPF-FB treatment significantly enhanced neurobehavioral sensory and motor performance in sciatic nerve-injured rats.
Frontiers in Physiology, 2021 • April 30, 2021
Traumatic spinal cord injury (SCI) initiates a complex cascade of pathological events, including vascular disruption and blood-spinal cord barrier (BSCB) breakdown, which exacerbate inflammation and t...
KEY FINDING: Blood vessel vascularization and remodeling after SCI are critical for SCI repair and functional recovery.
Bioactive Materials, 2021 • April 13, 2021
This review focuses on anisotropic topography and scaffolds for regenerating long-gap PNI (>10 mm) and SCI, covering anatomies of native nerves/cords and requirements for regenerative scaffold designs...
KEY FINDING: Anisotropic structures resembling the native extracellular matrix (ECM) can effectively guide neural outgrowth and reconnection.
Stem Cell Research & Therapy, 2021 • May 27, 2021
This study investigates the role of CD157 in BMSC-mediated mitochondrial transfer to improve neuronal apoptosis and functional recovery after spinal cord injury (SCI). The results suggest that CD157 c...
KEY FINDING: CD157 expression on BMSCs is upregulated when co-cultured with injured VSC4.1 motor neurons.
四川大学学报（医学版）, 2021 • May 1, 2021
This review discusses the knowledge of exosomes and the research progress in the regeneration and repair of related connective tissues, including the regeneration of bones, cartilage, skin, spinal cor...
KEY FINDING: MSC-EXO具有促进软骨细胞的基质再生、加速软骨形成的作用.
J Korean Neurosurg Soc, 2021 • September 1, 2021
The study aimed to identify the ideal expression ratio of the Wnt3a gene transfected into MSC to maximize neuro-regenerative effects in a chronic rat SCI model. The results showed that enhanced gene e...
KEY FINDING: Enhanced gene expression of Wnt3a in hMSC can potentiate axonal regeneration and improve functional recovery in a rat model of chronic SCI.