Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 891-900 of 2,298 results
Molecular Therapy, 2021 • August 1, 2021
This study demonstrates that Gsx1 expression increases NSPCs and the generation of specific interneuron subtypes, including vGlut2+ and ChAT+ interneurons, and 5-HT neuronal activity, while reducing i...
KEY FINDING: Gsx1 expression increases the number of NSPCs in a mouse model of lateral hemisection SCI during the acute stage.
eLife, 2021 • May 14, 2021
This study investigates the mechanisms underlying spinal cord regeneration in axolotls, focusing on the spatiotemporal pattern of cell proliferation. It demonstrates that the regenerative response is ...
KEY FINDING: Spinal cord regeneration is consistent with a signal that recruits ependymal cells during approximately 85 hours after amputation within approximately 830 μm of the injury.
Neural Regen Res, 2021 • April 23, 2021
This study demonstrates that Id2 can accelerate axonal regeneration, promote neuromuscular reinnervation, and enhance functional improvement following sciatic nerve injury in mice. The researchers use...
KEY FINDING: Id2 was successfully delivered into spinal cord motor neurons projecting to the sciatic nerve.
PLoS Genetics, 2021 • April 29, 2021
The study establishes an efficient sCrRNA screening paradigm that involves a pre-screening step to compensate for inherent variability in sCrRNA activity and to identify highly active guides (haCRs) f...
KEY FINDING: Rapid screening method identifies genes necessary for nerve connection repair and inflammation control after spinal cord injury in zebrafish.
International Journal of Molecular Sciences, 2021 • April 9, 2021
This study demonstrates that both cell culture oxygen conditions and the mode of EV preparation significantly affect the function of human iPSC-EVs. Hypoxic conditioning of human iPSCs resulted in the...
KEY FINDING: iPSC-EVs derived from 1% oxygen culture exhibit significantly elevated angiogenic potential compared to EVs obtained at higher oxygen levels.
Cells, 2021 • April 14, 2021
This review discusses the potential and limitations of various MSC types documented in SCI clinical trials, emphasizing the importance of niche-specific MSCs for transplant-mediated repair. An ideal M...
KEY FINDING: BM-MSCs are the most clinically applied MSCs for SCI treatment, with 20 registered trials.
Cells, 2021 • April 10, 2021
This study demonstrates that hair-follicle-associated pluripotent (HAP) stem cells can be efficiently differentiated into dopaminergic neurons in vitro. These HAP stem cell-derived dopaminergic neuron...
KEY FINDING: Mouse HAP stem cells can efficiently differentiate into dopaminergic neurons when cultured in neural-induction medium.
International Journal of Molecular Sciences, 2021 • April 16, 2021
The study successfully isolated PNSCs from adult peripheral nerves, demonstrating their multipotent differentiation potential into various cell types and their ability to secrete neurotrophic factors....
KEY FINDING: PNSC spheroids significantly improved functional recovery in a rodent SCI model, as indicated by increased BBB scores compared to single-cell PNSCs and the SCI/PBS group.
Biomedicines, 2021 • April 27, 2021
This study introduces a novel ridged OPF+ scaffold design for spinal cord injury treatment, aiming to enhance axonal regeneration by increasing surface area and providing directional guidance. In vitr...
KEY FINDING: Laminin coating on OPF+ sheets significantly enhanced neurite outgrowth from whole DRG explants compared to fibronectin, collagen, or serum-coated sheets.
Cell Biosci, 2021 • April 1, 2021
The study identifies Mbp as a key gene in myelin-associated NPC axonal regeneration, based on bioinformatics analysis. In vivo experiments showed that Mbp-overexpressing NPCs enhanced locomotive recov...
KEY FINDING: Myelin promotes axonal outgrowth from NPCs in an Mbp-dependent manner, indicating Mbp's crucial role in this process.