Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 911-920 of 2,298 results
Stem Cell Research & Therapy, 2021 • June 8, 2021
This study investigates the use of 3D-printed nerve guidance conduits (NGCs) multi-functionalized with canine adipose-tissue-derived mesenchymal stromal cells (AdMSCs) embedded in heterologous fibrin ...
KEY FINDING: Nerve guidance conduits multi-functionalized with canine AdMSCs improved functional motor and electrophysiological recovery compared with PCL group after 12 weeks.
The Journal of Spinal Cord Medicine, 2023 • April 1, 2023
The study demonstrated fibrin niche aided stable differentiation of rat ADMSCs into neural progenitors. Fibrin matrix holds up the delivered progenitor cells in the SCI site. The H&E stained tissues r...
KEY FINDING: Fibrin matrix holds up the delivered progenitor cells in the SCI site.
International Journal of Molecular Sciences, 2021 • May 13, 2021
Human platelet lysate (HPL) is a valuable alternative to fetal bovine serum (FBS) as a cell culture medium supplement for various cell types, enabling animal serum-free cell propagation. Dedicated qua...
KEY FINDING: HPL promotes efficient cell proliferation, making it suitable for manufacturing cell therapeutics within reasonable timeframes.
International Journal of Molecular Sciences, 2021 • May 31, 2021
The study investigates a combination therapy for spinal cord injury (SCI) involving human-induced neural stem cells (iPSC-NSC), mesenchymal stem cells (MSC), and a curcumin nanoconjugate (PA-C). In vi...
KEY FINDING: PA-C treatment increases iPSC-NSC viability and enhances neurite elongation in vitro, suggesting a neuroprotective effect.
Brazilian Journal of Medical and Biological Research, 2021 • September 1, 2021
This study aimed to determine the effects of Nogo-A and its receptor on sciatic nerve repair in rats. Rats were divided into control, model (sciatic nerve transection), immediate repair, and delayed r...
KEY FINDING: The expression of Nogo-A and its receptor, NgR, significantly increased in the spinal cord and sciatic nerve tissues after sciatic nerve transection in rats.
STAR Protocols, 2021 • June 18, 2021
The study describes a protocol for genome-scale CRISPR screening in genetically engineered human pluripotent stem cells (hPSCs) using the PAX6 reporter and an inducible CRISPR/Cas9 knockout system. Th...
KEY FINDING: The protocol allows for the identification of genes that prevent lineage specification, termed Lineage Specification Preventing Genes (LPGs).
Neural Regeneration Research, 2022 • January 1, 2022
Axonal regeneration after spinal cord injury is hindered by severe inflammation, the formation of a cavity of injury (COI) or arachnoiditis, and the presence of myelin. Inhibition of inflammation is a...
KEY FINDING: Severe inflammation following SCI, lasting over 16 weeks, is destructive to adjacent white matter.
Frontiers in Robotics and AI, 2021 • May 28, 2021
This study investigates kinematic changes in blue-spotted salamanders (Ambystoma laterale) during hindlimb regeneration, comparing them with the amphibious fish Polypterus senegalus to understand loco...
KEY FINDING: Salamanders in the early stages of regeneration exhibit a higher undulation frequency, particularly around the pelvic girdle.
World Journal of Stem Cells, 2021 • May 26, 2021
The study investigates the safety and efficacy of intraspinal transplantation of directly reprogrammed neural precursor cells (drNPCs) in non-human primates with spinal cord injury (SCI). The results ...
KEY FINDING: Animals in the drNPC group demonstrated a significant recovery of the paralyzed hindlimb as well as recovery of somato-sensory evoked potential and motor evoked potential of injured pathways.
Stem Cell Reports, 2021 • July 13, 2021
This study demonstrates that activation of endogenous genes Ngn2 and Isl1 by CRISPRa enabled reprogramming of mouse spinal astrocytes and embryonic fibroblasts to motor neurons. These induced neurons s...
KEY FINDING: Activation of endogenous Ngn2 and Isl1 via CRISPRa successfully reprogrammed mouse spinal astrocytes and embryonic fibroblasts into motor neurons in vitro.