间充质干细胞来源的外泌体促进组织再生与重建的研究进展

Stem cell therapy is an effective strategy for tissue regeneration, offering a positive therapeutic effect for repairing defective tissues. The positive effects of stem cell therapy are mediated by exosomes released by the paracrine action of mesenchymal stem cells. Exosome-based tissue regeneration treatment measures have been extensively studied as a promising treatment strategy.

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  MSC-EXO具有促进软骨细胞的基质再生、加速软骨形成的作用.
• 2
  MSC-EXO可促进HUVECs的增殖和迁移，并上调VEGF和HIF-1α等血管生成相关基因，增加血管形成能力.
• 3
  MSC-EXO可参与皮肤创伤愈合的稳态、炎症、增殖和重塑4个阶段，通过介导炎症反应和免疫调节，以及对细胞增殖、迁移和基质形成等方面的促进，对皮肤损伤再生发挥积极作用。