Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 841-850 of 2,298 results
Scientific Reports, 2018 • October 5, 2018
This study explored methods to enhance the recovery of cells expressing OEC marker p75NTR from rat mucosa. Key bioprocessing fundamentals were identified that will underpin future development of OEC-b...
KEY FINDING: A 24-hour differential adhesion step significantly increased the expression of p75NTR, an OEC marker, to 73 ± 5% and 46 ± 18% on PDL and laminin matrices, respectively.
STEM CELLS, 2019 • January 1, 2019
This review discusses the preparation for a first-in-human clinical study of iPSC-based cell transplant for subacute SCI, conducted under Japan’s Act on the Safety of Regenerative Medicine. The study ...
KEY FINDING: Pre-evaluation of iPSCs and iPSC-NSPCs before transplantation is essential for the detection of “dangerous” iPSC-NS/PCs.
Neural Regeneration Research, 2019 • March 1, 2019
Spinal cord injury leads to persistent behavioral deficits because mammalian central nervous system axons fail to regenerate. In lampreys, axotomy due to spinal cord injury results in delayed apoptosi...
KEY FINDING: Delayed axon resealing correlates with retrograde apoptosis of spinal-projecting neurons in lampreys, and this can be reversed by inducing rapid membrane resealing with polyethylene glycol.
Stem Cell Reports, 2019 • February 12, 2019
The study investigated whether electroacupuncture (EA) could promote cell survival and synaptic transmission within a neural stem cell-derived neural network scaffold (NN) transplanted into a transect...
KEY FINDING: EA improved the survival, neuronal differentiation and synapse formation of transplanted neural networks in the injured spinal cord.
Journal of Clinical Medicine, 2019 • January 23, 2019
This study investigated the effects of environmental lighting conditions on neural repair following experimental spinal cord injury (SCI) in rats, focusing on the role of endogenous melatonin. The key...
KEY FINDING: Constant darkness after SCI in rats led to a significant increase in motor recovery and body weight compared to normal or constant light conditions.
Neural Regen Res, 2019 • May 1, 2019
This study investigated the role of neural stem cell (NSC) transplantation in P2X receptor-mediated neuropathic pain in spinal cord injury (SCI) rats. The results showed that NSC transplantation reduc...
KEY FINDING: Neural stem cell transplantation markedly increased neurofilament protein expression in the injured spinal cord segment 4 weeks post-transplantation.
Neural Regen Res, 2019 • May 1, 2019
This study investigated the relationship between tau protein levels in serum and cerebrospinal fluid (CSF) and the severity and functional outcome of traumatic spinal cord injury (SCI) in rats. The st...
KEY FINDING: Tau protein levels in serum and CSF increased rapidly after SCI, peaking at 12 hours.
Bioactive Materials, 2025 • September 19, 2024
This study introduces a novel therapeutic strategy for spinal cord injury (SCI) repair using a temperature-responsive hyaluronic acid conjugated hydrogel-polydopamine nanoparticles (PDA NPs) combined ...
KEY FINDING: PDA NPs reduce intracellular ROS levels by 65 % and suppress the expression of inflammatory cytokines such as IL-1β (decreased by 35 %) and IL-6 (decreased by 23 %) in microglia cells.
Ann Neurosci, 2018 • April 25, 2018
This study investigates the potential of bone marrow mesenchymal stem cells (BM-MSCs) to promote motor recovery in rat models of spinal cord injury (SCI). The researchers transplanted cultured MSCs in...
KEY FINDING: Rat MSCs expressed positivity for MSC markers CD29, CD54, CD90, CD73, and CD105, and negativity for hematopoietic markers CD34, CD14, and CD45, indicating purity of MSCs.
J Zhejiang Univ-Sci B, 2019 • March 1, 2019
This review discusses comprehensive therapeutics targeting the corticospinal tract (CST) following spinal cord injury (SCI). It highlights the importance of the CST in motor function and the challenge...
KEY FINDING: The cortex of corticospinal motor system has huge potential for compensation, which is helpful to functional recovery.