Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 831-840 of 2,298 results
Physiol Rep, 2018 • June 1, 2018
The study aimed to determine if spinal cord injury affects the intrinsic ability of satellite cells to differentiate and produce metabolically healthy myotubes. The results indicate that the intrinsic...
KEY FINDING: Satellite cells from spinal cord-injured individuals retain the capacity to differentiate into myotubes.
International Journal of Molecular Sciences, 2018 • June 15, 2018
Chronic spinal cord injury lacks effective treatments, but regenerative medicine offers hope through stem cells, molecular therapies, and biomaterials. Clinical trials are underway using various stem ...
KEY FINDING: Several stem cell therapies have reached Phase II clinical trials, showing promise in restoring neurological function after chronic SCI.
Neural Regen Res, 2018 • June 1, 2018
This study investigated the efficacy of systemic mesenchymal stem cell (MSC) transplantation, via intravenous and intraperitoneal routes, for treating compressive spinal cord injury (SCI) in mice. The...
KEY FINDING: Both intravenous and intraperitoneal injections of MSCs resulted in white matter preservation in the injured spinal cord compared to control groups.
Cell Transplantation, 2018 • July 1, 2018
This study compares adipose-derived mesenchymal stromal cells (AD-MSCs) and bone marrow-derived mesenchymal stromal cells (BM-MSCs) in the treatment of spinal cord injury (SCI). The research evaluates...
KEY FINDING: AD-MSCs and BM-MSCs exhibit similar cell surface marker profiles but differ in their expression levels of growth factors and cytokines.
Exp Neurol, 2018 • November 1, 2018
The study investigated the combined effects of OEC transplantation, epidural stimulation, and motor training on axon regeneration in rats with spinal cord transection. Results showed increased axonal ...
KEY FINDING: OEC transplantation, combined with epidural stimulation and climb training, facilitated serotonergic- and neurofilament-labeled axon projections into the injury site.
Cell Transplantation, 2018 • September 1, 2018
This study investigates the effects of storing olfactory bulb (OB) tissue in various media for 24 and 48 hours on the yield and proportions of olfactory ensheathing cells (OECs) and olfactory nerve fi...
KEY FINDING: Storing olfactory bulb tissue for more than 24 hours negatively impacts the total cell number and the OEC population. Specifically, storing OBs rather than immediate culture (0 hour) causes a loss to the cell population.
Neural Regen Res, 2018 • September 1, 2018
This study investigates the effect of Saikosaponin a (SSa) on nerve regeneration and scar formation following sciatic nerve injury (SNI) in rats. SSa is a molecule with known anti-inflammatory propert...
KEY FINDING: Saikosaponin a (SSa) treatment significantly increased interleukin-10 (IL-10) levels in rats with sciatic nerve injury (SNI) 7 days after injury, indicating an enhanced anti-inflammatory response.
International Journal of Molecular Sciences, 2023 • September 8, 2023
Exosomes, as key secretomes, have emerged as pivotal players in understanding and potentially treating SCI. This manuscript explored their multifaceted roles, from serving as transporters that can pas...
KEY FINDING: Exosomes and exosomal miRNAs enhance recovery from SCI by attenuating neuronal cell death. MSC exosomes have been shown to increase Bcl-2 expression and decrease Bax levels after systemic administration in an SCI mouse or rat model.
Cell Death & Disease, 2018 • August 1, 2018
This study explores the therapeutic potential of human menstrual blood-derived stem cells (MenSCs) for spinal cord injury (SCI) treatment in a rat model. The results showed that MenSCs transplantation...
KEY FINDING: MenSCs transplantation improved hind limb motor function in rats with spinal cord injury, as measured by BBB scores.
Nature, 2018 • September 1, 2018
The study investigates why axons fail to regrow across complete spinal cord injuries (SCI) in adults and identifies three essential mechanisms for developmental axon growth that are lacking or attenua...
KEY FINDING: Combined delivery of AAV-OIC plus FGF+EGF+GDNF synergistically facilitated robust propriospinal axon regrowth in mice, passing through non-neural lesion cores and astrocyte scar borders, and penetrating well into spared grey matter.