Motor Recovery after Transplantation of Bone Marrow Mesenchymal Stem Cells in Rat Models of Spinal Cord Injury

This research explores using bone marrow mesenchymal stem cells (BM-MSCs) to help rats recover from spinal cord injuries. The study investigates whether transplanting these cells can repair damage and improve motor function. The mesenchymal stem cells were isolated from the rats, grown in the lab, and then injected into the injured spinal cords of the rats. The stem cells were tracked and evaluated for their ability to differentiate into neural cells. The rat's motor skills were observed, as well as the electrical signals in their muscles. The results suggested that the stem cell transplant led to some motor recovery, and that the cells were able to turn into neurons in the damaged area.

• 1
  Rat MSCs expressed positivity for MSC markers CD29, CD54, CD90, CD73, and CD105, and negativity for hematopoietic markers CD34, CD14, and CD45, indicating purity of MSCs.
• 2
  Transplanted GFP-labeled MSCs survived in the injured spinal cord, differentiated into neurons, and expressed β III tubulin, suggesting their role in spinal cord regeneration.
• 3
  Groups treated with BM-MSCs showed promising hind-limb motor recovery based on BBB scores, except for the control group, indicating functional recovery after transplantation.