Comprehensive therapeutics targeting the corticospinal tract following spinal cord injury

Spinal cord injury (SCI) is a difficult condition to recover from, often leading to movement and sensation problems. This paper focuses on the corticospinal tract (CST), a crucial part of the nervous system for controlling voluntary movement. The paper reviews various treatment strategies targeting different aspects of SCI, with a focus on treatments that specifically help the CST. Taking a comprehensive approach is often better than implementing a simple mean. Researchers have been working on various approaches, including tackling extensive regions, providing a regenerative microenvironment, transplantation, and rehabilitation training. The paper emphasizes that a multifaceted problem needs combinatorial approaches.

• 1
  The cortex of corticospinal motor system has huge potential for compensation, which is helpful to functional recovery.
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  Melatonin, a kind of intense antioxidant, can not only cover the aforementioned six areas, but also restrain amyloid-β peptide fibril formation, a formation which will lead to dysfunction of the brain.
• 3
  Incomplete SCI, spare tracts will generate intraspinal circuits boosting the post-damaged function, which is led by CST sprouting into the propriospinal neurons.