Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 851-860 of 2,298 results
Front. Cell. Neurosci., 2019 • February 26, 2019
This study aimed to determine the role of the locus coeruleus (LC) in the effects of treadmill running (TR) on spinal changes after peripheral nerve injury (PNI). The LC was chemically destroyed using...
KEY FINDING: Destruction of the LC blocked the ability of treadmill running to prevent synaptic stripping and the reduction in the thickness of perineuronal nets (PNN) on axotomized motoneurons.
BioMed Research International, 2019 • February 25, 2019
Stem cell transplantation is a promising method for treating neurodegenerative conditions, spinal cord injury, and stroke. Cellular therapies combined with neurorehabilitation yield better outcomes co...
KEY FINDING: Mesenchymal stem cell transplantation can remarkably improve the neurological function of SCI in animals without any severe side effect.
Pharmaceuticals, 2019 • April 29, 2019
This review summarizes the potential of neural stem cells (NSCs) as a therapeutic approach for spinal cord injury (SCI), highlighting their regenerative properties and ability to restore damaged neuro...
KEY FINDING: NSCs have shown regenerative effects in SCI models by providing neurotrophic support and restoring synaptic connectivity.
Cell Transplantation, 2019 • April 19, 2019
This review summarizes the author's work on functional multipotency of stem cells and recovery neurobiology of injured spinal cords, highlighting the limitations of traditional approaches to SCI treat...
KEY FINDING: Stem cells, including NSCs and MSCs, can exert multiple biofunctions, such as mitigating secondary injury attacks, promoting neural repair, and activating alternative neural pathways.
PNAS, 2004 • June 8, 2004
This study demonstrates that rolipram, a phosphodiesterase inhibitor, can promote axonal regeneration and functional recovery after spinal cord injury in rats. Rolipram overcomes inhibitors of regener...
KEY FINDING: Rolipram overcomes inhibition by myelin in culture, promoting neurite outgrowth of DRG neurons.
Frontiers in Cellular Neuroscience, 2019 • June 6, 2019
This review outlines the pathophysiology of SCI, focusing on factors that hinder regeneration, such as inflammation, scar formation, and CSPGs. It discusses strategies to reestablish connectivity with...
KEY FINDING: Stem cell transplantation can lead to remyelination of axons, secretion of regenerative neurotrophic factors, and synaptic reorganization, contributing to functional improvements after SCI.
Cell Transplantation, 2019 • May 16, 2019
This study explores the anatomical changes associated with olfactory ensheathing cell (OEC) transplantation after dorsal root injury, focusing on the interaction between transplanted cells and the per...
KEY FINDING: Transplanted OECs can survive at the dorsal root entry zone and bridge the gap between the peripheral and central nervous systems after injury.
Spinal Cord Series and Cases, 2019 • April 18, 2019
This case report presents the successful treatment of chronic refractory shoulder pain in a 54-year-old male with a T10 complete SCI using ultrasound-guided injection of autologous MFAT. The patient, ...
KEY FINDING: The patient experienced complete relief from pain, which was maintained at the 1-year follow-up after receiving the MFAT injection.
Mol Brain, 2021 • April 30, 2021
This study investigates the effects of repeated mesenchymal stem cell (MSC) infusions on the SOD1G93A transgenic ALS rat model, comparing it to single infusions and vehicle infusions. The results indi...
KEY FINDING: Repeated infusions of MSCs significantly extended the lifespan of the ALS rat model compared to a single infusion or vehicle control.
Exp Neurol, 2012 • September 1, 2012
The study examines combinations of pharmacological approaches to promote axonal regeneration after CNS injury, focusing on blocking glial inhibitors and activating intrinsic neuronal growth pathways. ...
KEY FINDING: NgR1 deletion in mice resulted in substantial optic nerve regeneration, comparable to that achieved by macrophage activation through zymosan injection.