Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 491-500 of 2,298 results
The Journal of Neuroscience, 2019 • March 13, 2019
This study establishes a workflow template from cell culture to animals in which microtubule-based treatments can be tested for their effectiveness in augmenting regeneration of injured axons relevant...
KEY FINDING: Knockdown of fidgetin resulted in faster-growing axons on both laminin and aggrecan and enhanced crossing of axons from laminin onto aggrecan in vitro.
Anat Rec (Hoboken), 2012 • October 1, 2012
This study provides a histological comparison of the mature regenerated and original tail of the lizard Anolis carolinensis. The regenerated tail has a cartilage skeleton enclosing a spinal cord but l...
KEY FINDING: The regenerated tail has a cartilage tube with foramina, enclosing a spinal cord with an ependymal core, but no regeneration of dorsal root ganglia or peripheral nerves.
International Journal of Nanomedicine, 2025 • March 8, 2025
The study successfully constructed a hydrogel-loaded lyophilized hucMSCs-exo drug delivery system, which is called exo@H, and demonstrated its effectiveness in treating periodontitis in mice. Exo@H pr...
KEY FINDING: Lyophilized hucMSCs-exo promoted the proliferation and osteogenic differentiation of MC3T3-E1 cells, and showed more significant abilities in combination with hydrogel.
Neural Regeneration Research, 2017 • May 1, 2017
This study explores the dual role of chondroitin sulfate proteoglycans (CSPGs) in neural regeneration, highlighting their potential to switch from inhibitors to promoters of regeneration under specifi...
KEY FINDING: HB-GAM can reverse the inhibitory effect of CSPGs on neurite outgrowth in vitro, promoting growth instead.
International Journal of Molecular Sciences, 2020 • September 24, 2020
The study screened small organic compounds for their ability to mimic the HNK-1 carbohydrate, which is known to play a role in preferential motor reinnervation after nerve injury. Six compounds were i...
KEY FINDING: Six small organic compounds (ursolic acid, indirubin, tosufloxacin, 5-nonyloxytryptamine, hexachlorophene, and tamoxifen) were identified as HNK-1 mimetics using a competitive ELISA.
Exp Neurol, 2015 • January 1, 2015
The study investigates whether inhibiting kinesin-5 with monastrol can improve axonal regeneration after spinal cord injury (SCI) when combined with ChABC treatment. Monastrol enhanced axonal regenera...
KEY FINDING: Monastrol treatment, combined with ChABC, significantly enhanced axonal regeneration after spinal cord injury in rats.
BMC Neurology, 2009 • July 15, 2009
This study investigates the expression patterns of CSPG family members (NG2, neurocan, versican, and phosphacan) in post-mortem human spinal cord samples after traumatic SCI to understand their role i...
KEY FINDING: NG2 and phosphacan were both detected in the evolving astroglial scar after human SCI, suggesting they might hinder CNS regeneration.
Journal of Oral Biology and Craniofacial Research, 2017 • February 4, 2017
Stem cells possess self-renewal and differentiation capabilities, holding potential for treating various conditions, including tooth loss. Dental stem cells, easily accessible, offer promise in treati...
KEY FINDING: Dental stem cells are found in primary and permanent teeth, including wisdom teeth, making them a readily available resource.
Dev Dyn, 2021 • June 1, 2021
This study investigates the effects of CoCl2, a chemical that induces hypoxia and cellular stress, on axolotl tail regeneration, particularly in the context of romidepsin-induced regeneration inhibiti...
KEY FINDING: CoCl2 can partially rescue the inhibitory effect of romidepsin on tail regeneration when co-administered for 1 minute post-amputation (MPA).
Neural Regeneration Research, 2021 • February 19, 2021
This review focuses on the role of post-translational modifications (PTMs) in influencing axonal growth, functional recovery, and neuropathic pain following spinal cord injury (SCI). The authors highl...
KEY FINDING: PTMs like phosphorylation, acetylation, detyrosination, and polyglutamylation modify tubulin, influencing microtubule functions essential for neurite outgrowth and growth cone guidance during nerve regeneration after SCI.