Miracle cells for natural dentistry – A review

Journal of Oral Biology and Craniofacial Research, 2017 · DOI: 10.1016/j.jobcr.2015.11.007 · Published: February 4, 2017

Regenerative Medicine Biomedical

Simple Explanation

Stem cells are unique because they can renew themselves and turn into different types of cells in the body. This makes them useful for repairing or replacing damaged tissues. Dental stem cells, found in teeth, are easy to collect and have the potential to treat various conditions, including cancer and spinal cord injuries. Researchers are exploring how stem cells can regenerate dental tissues, offering alternatives to traditional treatments like prosthetics and implants.

Study Duration

Not specified

Participants

Not specified

Evidence Level

Review Article

Key Findings

1
Dental stem cells are found in primary and permanent teeth, including wisdom teeth, making them a readily available resource.
2
Dental stem cells have the potential for various therapeutic applications, including treating cancer, spinal cord injury, and myocardial infarction.
3
Stem cells can be used to regenerate dental hard tissues like enamel and dentin, as well as soft tissues like pulp and periodontal tissue.

Research Summary

Stem cells possess self-renewal and differentiation capabilities, holding potential for treating various conditions, including tooth loss. Dental stem cells, easily accessible, offer promise in treating cancer, spinal cord injury, and other conditions, potentially regenerating damaged dental tissues. Stem cell-based tooth engineering aims to replace lost teeth with natural ones, but further research is needed to refine treatment modalities.

Practical Implications

Regenerative Endodontics

Stem cells offer a biologically based approach to replace damaged tooth structures, including dentin and root structures.

Periodontal Regeneration

Growth and differentiation factors used with stem cells can regenerate periodontal tissues, potentially reversing damage from periodontal disease.

Whole Tooth Regeneration

Stem cells, cultured on scaffolds and implanted, can regenerate entire teeth, offering a future alternative to prosthetics.

Study Limitations

1
The risk of teratogenic effects due to the potential for malignant transformation of stem cells.
2
Potential immune responses that may affect the host's immune system.
3
Viral and microbial safety concerns associated with the manufacturing of cell-based products.

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