Regenerative Medicine Research

KEY FINDING: bFGF acts through binding to tyrosine kinase FGF receptors on the cell membrane, triggering intracellular signaling pathways that initiate cell migration, proliferation, and differentiation.

KEY FINDING: Chronic stress impairs sensory axon regeneration in a preconditioning lesions mouse model.

KEY FINDING: Peripheral nerve injury induces a series of changes from the central nervous system to the peripheral nervous system and target organs, impacting cortical plasticity, spinal cord neurons, and muscle tissue.

KEY FINDING: C2SH causes marked EMG deficits across ventilatory behaviours

KEY FINDING: Laurus nobilis extract-loaded scaffolds reduced tissue expression levels of pro-inflammatory cytokines like TNF-a, IL-1b, and IL-6.

KEY FINDING: Inhibition of Chst15 impairs the deposition of CSPGs in the extracellular matrix and the migration of astrocytes, which are key processes in glial scar formation after SCI.

KEY FINDING: Mitochondrial dysfunction is intimately linked with axonal regeneration failure in the context of spinal cord injury.

KEY FINDING: SRF expression in injured spinal cord gray matter neurons gradually increased, peaking on the 7th day after injury.

KEY FINDING: MSCs can regulate macrophage polarization by secreting soluble proteins, including ILs and chemokines, which ultimately relieve SCI.

KEY FINDING: Distinct progenitor origins (NEP vs. NMP) lead to differences in gene expression and chromatin accessibility in V2a neurons, even under identical differentiation conditions.