Regenerative Medicine Research

KEY FINDING: All three surgical approaches (SCT, vSCT, and vASCT) demonstrated the potential to partially restore motor function in beagles with complete SCI.

KEY FINDING: Transcutaneous spinal cord stimulation (tSCS) coupled with inspiratory muscle training (IMT) increases patients’ respiratory capacity, whereas IMT alone does not.

KEY FINDING: Cryopreserved NES cells maintain high cell viability and retain their cell identity and differentiation capacity after thawing.

KEY FINDING: hUMSCs can promote the recovery of motor and urinary function in SCI patients, with some clinical studies showing significant improvements in motion, self-care ability, and muscle tension.

KEY FINDING: Multi-drug and short-term immunosuppression regimens are commonly employed in stem cell trials involving retinal and neural cells.

KEY FINDING: PlexinA4 is widely expressed throughout the adult rat brain, including the cortex, hippocampus, brainstem, pontine and medullary nuclei.

KEY FINDING: BM accelerated the recovery of motor function in rats with central nervous system injuries.

KEY FINDING: Histone acetylation influences neural plasticity, synaptogenesis, and synaptic plasticity, impacting tissue remodeling post-SCI. Specifically, H4 acetylation levels are time-related and affect glial fibrillary acidic protein levels.

KEY FINDING: PAD3 expression increases with development and is further upregulated after spinal cord injury, particularly at stages when regeneration is less effective.

KEY FINDING: Extrusion technology generates nanosized vesicles in far greater numbers than naturally obtained EVs.