Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 461-470 of 2,298 results
Stem Cells Translational Medicine, 2024 • February 7, 2024
This study introduces a microfluidic separation technology to remove residual undifferentiated iPSCs from iPSC-derived spinal cord progenitor cells (SCPCs), addressing the risk of tumor formation post...
KEY FINDING: Large-sized SCPCs after 10-day differentiation contain more cells expressing pluripotent markers, indicating residual undifferentiated iPSCs.
Stem Cell Research & Therapy, 2024 • January 29, 2024
The study investigates the therapeutic potential of co-transplanting iPSC-derived OPCs with HUVECs in a rat model of spinal cord injury (SCI). Results demonstrated that HUVECs enhance OPC proliferatio...
KEY FINDING: HUVECs promote the proliferation, migration, and survival of OPCs both in vitro and in vivo.
Scientific Reports, 2024 • February 2, 2024
This study investigated the combined therapeutic effects of laser-activated stromal vascular fraction (SVF) and platelet-rich plasma (PRP) on spinal cord injury in a feline model of multiple sclerosis...
KEY FINDING: Combining SVF and PRP reduced lesion intensity on MRI scans and improved the physical condition of the cats.
Frontiers in Neuroscience, 2024 • January 24, 2024
In this study, we used a combination of bibliometric and visualized analyses to generate a representation of the current state of stem cell therapy for spinal cord injury. China has the highest number...
KEY FINDING: The USA and China made the highest contributions to global research with the highest number of citations and link strength.
Int. J. Mol. Sci., 2024 • January 26, 2024
The treatment of spinal cord injury (SCI) with uncultivated human bone marrow-derived stromal cells (bmSCs) prepared by negative selection has been proposed to be therapeutically superior to treatment...
KEY FINDING: Treatment resulted in a significant, dose-dependent therapeutic effect on the recovery of motor performance.
Iran. J. Biotechnol., 2023 • July 1, 2023
This study investigated the therapeutic potential of AD-MSC-DE encapsulated within collagen and fibrin hydrogels for treating spinal cord injury (SCI) in a rat model. The results demonstrated that AD-...
KEY FINDING: AD-MSC-DE encapsulated into fibrin and collagen hydrogels improved clinical function in SCI rats compared to the control group.
Stem Cell Reports, 2024 • March 12, 2024
This study demonstrates that ex vivo gene therapy with CPTX-expressing hiPSC-NS/PCs enhances synapse formation and functional recovery in a rat model of SCI. The findings indicate that CPTX promotes t...
KEY FINDING: CPTX expression in transplanted hiPSC-NS/PCs significantly increased excitatory synapse formation at the transplantation site.
Frontiers in Genetics, 2024 • February 6, 2024
This study conducted a bibliometric analysis of stem cell therapy for spinal cord injury research from 2018 to 2023, utilizing databases like Web of Science and tools like CiteSpace and VOSviewer. The...
KEY FINDING: The number of publications on stem cell therapy for SCI has been steadily increasing from 2018 to 2023, indicating growing interest in the field.
Int. J. Mol. Sci., 2024 • February 18, 2024
This study investigates the therapeutic potential of MSC-derived exosomes in alleviating spinal cord injury (SCI) by modulating neutrophil extracellular trap (NET) formation. The research focuses on t...
KEY FINDING: Exosome treatment improved motor function recovery and reduced injury size in rats with spinal cord injuries.
Cell Communication and Signaling, 2024 • December 11, 2024
This study investigates the role of UTX, an epigenetic regulator, in endothelial cells following spinal cord injury (SCI), focusing on its impact on neural stem cell (NSC) differentiation. The researc...
KEY FINDING: UTX knockout in spinal cord microvascular endothelial cells (SCMECs) enhances neurogenesis in a mouse model of spinal cord injury (SCI).