Improved Efficacy of Delayed Treatment with Human Bone Marrow-Derived Stromal Cells Evaluated in Rats with Spinal Cord Injury

This study explores using human bone marrow cells to treat spinal cord injuries in rats. The cells are prepared in a special way, and the treatment is given a week after the injury. Researchers looked at how well the rats recovered their movement and checked their spinal cords for signs of improvement. They found that a higher dose of cells helped the rats move better and reduced damage in the spinal cord. This suggests that using these specially prepared bone marrow cells could be a helpful treatment for spinal cord injuries, especially when given after the initial injury phase.

• 1
  Treatment resulted in a significant, dose-dependent therapeutic effect on the recovery of motor performance.
• 2
  The histological analysis revealed a lower degree of axonal degeneration and better survival of neurons and oligodendrocytes in bmSCs treated rats.
• 3
  Treatment with the higher dose of human bmSCs had a sustained therapeutic benefit, but not the lower dose nor our preparation of stromal cells from rat bone marrow.